Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer.
CAT No: HB00109
CAS No:196078-30-5
Chemical Name:(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-4-amino-1-[[(2S)-1-[[2-[(2S)-2-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[(2S)-2-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]-2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-4-amino-2-[[(2R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]-3-sulfanylpropanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]pentanediamide
Pramlintide Acetate is a synthetic peptide analog of human amylin, a hormone co-secreted with insulin by pancreatic beta cells. As a peptide compound, it is structurally engineered to mimic the physiological actions of endogenous amylin, while exhibiting enhanced stability and solubility for research use. Its unique sequence modifications confer resistance to aggregation, making it a valuable tool for studying peptide hormone function and receptor interactions. Pramlintide Acetate's relevance extends across metabolic research, peptide-receptor pharmacology, and the investigation of amyloidogenic pathways, positioning it as an important reagent for advanced biochemical studies.
Peptide hormone signaling research: Pramlintide Acetate serves as a model compound for elucidating the mechanisms of amylin receptor activation and downstream signaling pathways. By providing a stable and bioactive analog, it enables detailed investigation of amylin's physiological roles in glycemic regulation, satiety control, and gastric emptying. Researchers utilize the peptide to dissect receptor subtype specificity, ligand binding kinetics, and the modulation of second messenger systems, thereby advancing the understanding of peptide hormone-receptor interactions in metabolic homeostasis.
Metabolic pathway studies: The analog's ability to replicate key actions of native amylin makes it an important tool for exploring glucose metabolism and energy balance in cellular and animal models. Investigators employ Pramlintide Acetate to probe the molecular basis of insulin-amylin synergy, assess its impact on hepatic glucose output, and characterize its influence on nutrient partitioning. These studies provide insights into the integrated hormonal regulation of metabolism and the pathophysiology of metabolic disorders.
Peptide aggregation and amyloidogenesis research: Pramlintide Acetate's engineered sequence offers a unique opportunity to examine the structural determinants of peptide aggregation and amyloid formation. Its resistance to fibril formation, compared to wild-type amylin, allows for comparative analyses that shed light on amyloidogenic motifs and aggregation-prone regions. Researchers leverage this property to investigate the molecular mechanisms underlying islet amyloidosis and to develop strategies for modulating peptide aggregation in vitro.
Peptide synthesis and formulation development: The compound is frequently used as a reference standard and positive control in the development and validation of synthetic peptide production methods. Its well-characterized sequence and physicochemical properties make it suitable for optimizing solid-phase peptide synthesis protocols, peptide purification workflows, and formulation strategies aimed at improving peptide solubility and stability. Analytical laboratories and process development teams benefit from its application in method development and quality assessment.
Analytical assay calibration: Pramlintide Acetate is employed as a calibration standard in quantitative analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and immunoassays designed to detect and quantify amylin-related peptides. Its defined structure and consistent performance facilitate the establishment of reliable calibration curves, method validation, and assay reproducibility. These applications are essential for accurate quantification of peptide hormones in complex biological matrices and for ensuring data integrity in biochemical research.
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