Insulin Aspart is a recombinant human insulin analog with rapid-acting, blood glucose-lowering activity. Insulin aspart, acting faster than regular human insulin, regulates glucose metabolism by binding to insulin receptors on muscle and fat cells, thereby facilitating the cellular uptake of glucose. This lowers blood glucose levels. At the same time, insulin aspart inhibits the liver's conversion of stored glycogen into glucose, which also contributes to lower blood glucose levels. Insulin aspart also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis.
CAT No: 10-101-330
CAS No:116094-23-6
Synonyms/Alias:L-phenylalanyl-L-valyl-L-asparagyl-L-glutaminyl-L-histidyl-L-leucyl-L-cysteinyl-glycyl-L-seryl-L-histidyl-L-leucyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-leucyl-L-tyrosyl-L-leucyl-L-valyl-L-cysteinyl-glycyl-L-alpha-glutamyl-L-arginyl-glycyl-L-phenylalanyl-L-phenylalanyl-L-tyrosyl-L-threonyl-L-alpha-aspartyl-L-lysyl-L-threonine (7->7'),(19->20')-bis(disulfide) compound with glycyl-L-isoleucyl-L-valyl-L-alpha-glutamyl-L-glutaminyl-L-cysteinyl-L-cysteinyl-L-threonyl-L-seryl-L-isoleucyl-L-cysteinyl-L-seryl-L-leucyl-L-tyrosyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-asparagyl-L-tyrosyl-L-cysteinyl-L-asparagine (6'->11')-disulfide
Chemical Name:(4S)-4-[[2-[[(1R,6R,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,50S,53S,56S,59S,62S,65S,68S,71S,74R,77S,80S,83S,88R)-88-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]-6-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-47-[[(1S)-3-amino-1-carboxy-3-oxopropyl]carbamoyl]-53-(2-amino-2-oxoethyl)-62-(3-amino-3-oxopropyl)-77-[(2S)-butan-2-yl]-24,56-bis(2-carboxyethyl)-83-[(1R)-1-hydroxyethyl]-12,71,80-tris(hydroxymethyl)-33,50,65-tris[(4-hydroxyphenyl)methyl]-15-(1H-imidazol-4-ylmethyl)-27-methyl-18,30,36,59,68-pentakis(2-methylpropyl)-7,10,13,16,19,22,25,28,31,34,37,40,49,52,55,58,61,64,67,70,73,76,79,82,85,87-hexacosaoxo-21,39-di(propan-2-yl)-3,4,44,45,90,91-hexathia-8,11,14,17,20,23,26,29,32,35,38,41,48,51,54,57,60,63,66,69,72,75,78,81,84,86-hexacosazabicyclo[72.11.7]dononacontane-42-carbonyl]amino]acetyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
Insulin aspart, a rapid-acting recombinant insulin analog, is widely recognized for its structural modifications that enable faster absorption and onset of action compared to regular human insulin. Engineered through the substitution of proline with aspartic acid at position B28, this peptide demonstrates enhanced solubility and reduced self-association, making it highly suitable for research environments that require precise control of glucose metabolism. Its stability in solution and predictable pharmacokinetic profile have contributed to its popularity in experimental settings, where reproducibility and accuracy are paramount. Researchers value insulin aspart for its ability to closely mimic endogenous prandial insulin secretion, facilitating a range of studies focused on metabolic regulation and cellular glucose uptake.
Metabolic Research: In metabolic research, insulin aspart serves as a vital tool for investigating the mechanisms underlying glucose homeostasis and insulin signaling pathways. Scientists utilize this analog to stimulate glucose uptake in cultured cell lines, isolated tissues, and animal models, providing insight into insulin receptor activation, downstream signaling cascades, and the modulation of key metabolic enzymes. Its rapid and predictable action enables the dissection of acute insulin responses, supporting studies that explore insulin sensitivity, resistance, and the impact of various interventions on metabolic health. By employing insulin aspart, researchers can model postprandial glucose excursions and evaluate the efficacy of novel compounds or genetic modifications in regulating glucose dynamics.
Cellular and Molecular Biology: Within the field of cellular and molecular biology, the application of insulin aspart extends to the analysis of gene expression, protein synthesis, and intracellular trafficking related to insulin-responsive pathways. Investigators often use this insulin analog to trigger signal transduction events, such as the phosphorylation of Akt and translocation of glucose transporter proteins (e.g., GLUT4), in both in vitro and ex vivo systems. This facilitates the study of cellular responses to insulin at the molecular level, enabling a deeper understanding of the regulatory networks that govern glucose metabolism, lipid synthesis, and cell growth. Additionally, insulin aspart provides a reliable means to assess the functional consequences of genetic mutations or pharmacological interventions targeting insulin signaling components.
Islet Cell Physiology: Insulin aspart is frequently employed in studies of pancreatic islet cell physiology, where it aids in elucidating the dynamics of insulin secretion and feedback regulation. By applying this analog to isolated islets or perfused pancreas preparations, researchers can investigate the effects of exogenous insulin on beta-cell function, intra-islet communication, and paracrine interactions with other endocrine cell types. These experiments contribute to the understanding of islet adaptation, dysfunction, and the interplay between insulin and other hormones, which is critical for advancing knowledge in the field of diabetes research and islet transplantation.
Pharmacological Screening: In pharmacological screening assays, insulin aspart is an indispensable reference compound for evaluating the activity of candidate molecules that modulate insulin signaling or glucose uptake. Its well-characterized action profile allows for the establishment of robust assay systems, enabling the comparison of new compounds against a standard rapid-acting insulin analog. Researchers utilize these assays to identify potential insulin mimetics, sensitizers, or inhibitors, supporting the development of therapeutic strategies for metabolic disorders. The use of insulin aspart in high-throughput screening and mechanistic studies accelerates the discovery and optimization of novel agents targeting the insulin signaling axis.
Biotechnology and Bioengineering: The versatility of insulin aspart extends to biotechnology and bioengineering applications, where it is employed to optimize cell culture systems and bioprocesses that require precise regulation of nutrient uptake and cellular metabolism. In biomanufacturing, the addition of this insulin analog to culture media enhances the growth and productivity of mammalian cells, particularly in the production of recombinant proteins and antibodies. By fine-tuning the timing and concentration of insulin aspart supplementation, researchers and engineers can improve cell viability, metabolic efficiency, and product yield, making it a valuable component in the optimization of scalable and reproducible bioprocesses.
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