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Ziconotide

Ziconotide is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Ziconotide(CAS 107452-89-1)

CAT No: 10-101-62

CAS No:107452-89-1

Synonyms/Alias:Ziconotide;Prialt;omega-conotoxin MVIIA;SNX-111;107452-89-1;omega-Conotoxin M VIIA;Ziconotida;omega-Conopeptide MVIIA (Conus);DRG-0250;UNII-7I64C51O16;HSDB 7609;MFCD00145036;150770-63-1;DTXSID60883174;omega-Conotoxin M VIIA (reduced), cyclic (1-16),(8-20),(15-25)-tris(disulfide);7I64C51O16;H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cy;omega-Conotoxin mviia, conus magus;Ziconotide [USAN:INN];ziconotidum;o-Conotoxin MVIIA;.omega.-conotoxin m viia;ZICONOTIDE (MART.);GTPL2536;CHEMBL4594214;N02BG08;CHEBI:135912;CHEBI:142406;DTXCID901323852;HY-P0062;AKOS015994641;AC-8938;AT42420;HS-2032;FC110295;omega-Conotoxin MVIIA, >=95% (HPLC);CS-0015087;NS00068028;?-Conotoxin M VIIA Acetate; ?-Conopeptide MVIIA Acetate; Prialt Acetate; SNX 111;;L-Cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-seryl-L-arginyl-L-leucyl-L-methionyl-L-tyrosyl-L-alpha-aspartyl-L-cysteinyl-L-cysteinyl-L-threonylglycyl-L-seryl-L-cysteinyl-L-arginyl-L-serylglycyl-L-lysyl-L-cysteinamide cyclic (1-16),(8-20),(15-25)-tris(disulfide);

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cGMP Peptide
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M.F/Formula
C102H172N36O32S7
M.W/Mr.
2639.2
Sequence
One Letter Code:CKGKGAKCSRLMYDCCTGSCRSGKC
Three Letter Code:H-Cys(1)-Lys-Gly-Lys-Gly-Ala-Lys-Cys(2)-Ser-Arg-Leu-Met-Tyr-Asp-Cys(3)-Cys(1)-Thr-Gly-Ser-Cys(2)-Arg-Ser-Gly-Lys-Cys(3)-NH2
Appearance
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research.
Activity
Antagonist
Target
Calcium Channel
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C102H172N36O32S7/c1-50(2)34-63-91(161)127-62(26-33-171-5)90(160)129-64(35-53-22-24-54(143)25-23-53)92(162)130-65(36-78(148)149)93(163)135-72-48-175-173-45-69(80(108)150)133-86(156)58(18-8-12-29-105)121-76(146)39-117-85(155)66(41-139)131-88(158)61(21-15-32-114-102(111)112)126-96(166)70-46-176-177-47-71(97(167)132-68(43-141)95(165)125-60(87(157)128-63)20-14-31-113-101(109)110)134-89(159)59(19-9-13-30-106)123-81(151)51(3)119-74(144)37-115-83(153)56(16-6-10-27-103)120-75(145)38-116-84(154)57(17-7-11-28-104)124-82(152)55(107)44-172-174-49-73(137-98(72)168)99(169)138-79(52(4)142)100(170)118-40-77(147)122-67(42-140)94(164)136-70/h22-25,50-52,55-73,79,139-143H,6-21,26-49,103-107H2,1-5H3,(H2,108,150)(H,115,153)(H,116,154)(H,117,155)(H,118,170)(H,119,144)(H,120,145)(H,121,146)(H,122,147)(H,123,151)(H,124,152)(H,125,165)(H,126,166)(H,127,161)(H,128,157)(H,129,160)(H,130,162)(H,131,158)(H,132,167)(H,133,156)(H,134,159)(H,135,163)(H,136,164)(H,137,168)(H,138,169)(H,148,149)(H4,109,110,113)(H4,111,112,114)/t51-,52+,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,79-/m0/s1
InChI Key
BPKIMPVREBSLAJ-QTBYCLKRSA-N

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