Natamycin is a polyene amphoteric macrolide antibiotic with antifungal properties. Natamycin exerts its antifungal effects by binding to sterols in the fungal cell membrane thereby increasing membrane permeability. This leads to a leakage and loss of essential cellular constituents. Following ocular application, natamycin is retained in the conjunctival fornices and attains effective concentrations within the corneal stroma where it exerts its effect.
CAT# | Z10-101-166 |
CAS | 7681-93-8 |
Synonyms/Alias | Pimaricin;Tennecetin; Myprozine; |
M.F/Formula | C33H47NO13 |
M.W/Mr. | 665.73 |
Labeling Target | 30s ribosomal subunit |
Application | Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid. |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Biological Activity | Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. |
Areas of Interest | Immunology & Inflammation Cell Biology Cancer |
Functions | Natamycin is used for a variety of fungal infections, mainly topically. |
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