Glatiramer acetate

Glatiramer acetate consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000-9,000 daltons. It is an immunomodulator, licensed in much of the world for reduced frequency of relapses in relapsing-remitting multiple sclerosis

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CAT#	10-101-164
CAS	147245-92-9
Synonyms/Alias	COP-1;Copolymer-1;Copoylmer 1
M.F/Formula	C254H422N70O72
M.W/Mr.	7000.0 Da (range 5000-9000)
Sequence	EAYKAAEKAYAAKEAAKEAAKAKAEKKAAYAKAKAAKYEKKAKKAAAEYKKK
Labeling Target	HLA class II histocompatibility antigen, DRB1-1 beta chain
Application	Glatiramer is for reduction of the frequency of relapses in patients with Relapsing-Remitting Multiple Sclerosis.
Activity	Binder
Biological Activity	Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells.
Areas of Interest	Neurological Disease
Functions	Virus receptor activity
Disease	Multiple sclerosis

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Source#	Synthetic
Storage	-20°C
Organism	Human
InChI	InChI=1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1
InChI Key	FHEAIOHRHQGZPC-KIWGSFCNSA-N
Isomeric SMILES	C[C@@H](C(=O)O)N.CC(=O)O.C1=CC(=CC=C1C[C@@H](C(=O)O)N)O.C(CCN)C[C@@H](C(=O)O)N.C(CC(=O)O)[C@@H](C(=O)O)N
BoilingPoint	385.2ºC at 760mmHg
Melting Point	N/A