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Glatiramer acetate

Glatiramer acetate consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000-9,000 daltons. It is an immunomodulator, licensed in much of the world for reduced frequency of relapses in relapsing-remitting multiple sclerosis

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: 10-101-164

CAS No:147245-92-9

Synonyms/Alias:COP-1;Copolymer-1;Copoylmer 1

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cGMP Peptide
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M.F/Formula
C254H422N70O72
M.W/Mr.
7000.0 Da (range 5000-9000)
Sequence
EAYKAAEKAYAAKEAAKEAAKAKAEKKAAYAKAKAAKYEKKAKKAAAEYKKK
Labeling Target
HLA class II histocompatibility antigen, DRB1-1 beta chain
Application
Glatiramer is for reduction of the frequency of relapses in patients with Relapsing-Remitting Multiple Sclerosis.
Activity
Binder
Biological Activity
Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells.
Areas of Interest
Neurological Disease
Functions
Virus receptor activity
Source#
Synthetic
Organism
Human
InChI
InChI=1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1
InChI Key
FHEAIOHRHQGZPC-KIWGSFCNSA-N
Isomeric SMILES
C[C@@H](C(=O)O)N.CC(=O)O.C1=CC(=CC=C1C[C@@H](C(=O)O)N)O.C(CCN)C[C@@H](C(=O)O)N.C(CC(=O)O)[C@@H](C(=O)O)N
BoilingPoint
385.2ºC at 760mmHg
Melting Point
N/A

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