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Suc-Leu-Tyr-AMC

Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease), and used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm). Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Suc-Leu-Tyr-AMC(CAS 94367-20-1)

CAT No: R0810

CAS No:94367-20-1

Synonyms/Alias:Suc-Leu-Tyr-AMC;Suc-LY-AMC;94367-20-1;Suc-Leu-Tyr-MCA;N-Succinyl-Leu-Tyr-7-amido-4-methylcoumarin;Suc-leu-tyr-nhmec;CHEBI:63170;N-(3-carboxy-1-oxopropyl)-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-tyrosinamide;Succinyl-leucyl-tyrosyl-4-methyl-7-coumarylamide;N-(3-carboxypropanoyl)-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tyrosinamide;MFCD00057900;N-Succinyl-Leu-Tyr 7-amido-4-methylcoumarin;CALPAIN SUBSTRATE I;RIYLNECMTVNMSO-GOTSBHOMSA-N;AKOS040755211;FS110527;TS-08846;HY-135172;CS-0109694;Q27132434;4-((S)-1-((S)-3-(4-hydroxyphenyl)-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopropan-2-ylamino)-4-methyl-1-oxopentan-2-ylamino)-4-oxobutanoic acid;L-Tyrosinamide,N-(3-carboxy-1-oxopropyl)-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-;

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cGMP Peptide
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  • CMC information required for an IND
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  • Drug master files (DMF) filing
M.F/Formula
C29H33N3O8
M.W/Mr.
551.6
Sequence
One Letter Code:LY
Three Letter Code:Suc-Leu-Tyr-AMC
Application
A fluorgenic substrate
Appearance
White to off-white powder
Purity
>98%
Areas of Interest
Cell Biology
Source#
Synthetic
Long-term Storage Conditions
Soluble in DMSO
InChI
InChI=1S/C29H33N3O8/c1-16(2)12-22(31-25(34)10-11-26(35)36)29(39)32-23(14-18-4-7-20(33)8-5-18)28(38)30-19-6-9-21-17(3)13-27(37)40-24(21)15-19/h4-9,13,15-16,22-23,33H,10-12,14H2,1-3H3,(H,30,38)(H,31,34)(H,32,39)(H,35,36)/t22-,23-/m0/s1
InChI Key
RIYLNECMTVNMSO-GOTSBHOMSA-N
Isomeric SMILES
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](CC(C)C)NC(=O)CCC(=O)O
BoilingPoint
945.5ºC at 760mmHg
Melting Point
N/A

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