Omiganan Pentahydrochloride (MBI 226), a Topical 12-Amino-Acid Cationic Peptide, has good antimicrobial activity and bactericidal activity.
CAT No: 10-101-93
CAS No:269062-93-3
Synonyms/Alias:Omiganan pentahydrochloride;269062-93-3;MBI 226;MBI-226;Omiganan (pentahydrochloride);626233-83-8;Omiganan HCl;UNII-LX2P9RD54V;Omiganan pentahydrochloride [USAN];LX2P9RD54V;CHEMBL1793889;EX-A7464;Cevidoplenib dimesylate hydrochloride;AT42482;HY-105048A;TS-10053;CS-0024803;L-Isoleucyl-L-leucyl-L-arginyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-L-arginyl-L-lysinamide pentahydrochloride;L-Lysinamide, L-isoleucyl-L-leucyl-L-arginyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-L-arginyl-, hydrochloride (1:5);L-Lysinamide, L-isoleucyl-L-leucyl-L-arginyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-L-arginyl-, pentahydrochloride;
Omiganan Pentahydrochloride is a synthetic cationic peptide that belongs to the class of antimicrobial peptides, specifically designed to mimic the innate immune system's natural defense mechanisms. Composed of a sequence of amino acids that confer both structural stability and functional specificity, this compound has garnered significant attention in biochemical research for its potent activity against a broad spectrum of microbial organisms. Its amphipathic and positively charged nature facilitates interactions with microbial membranes, making it a valuable tool for investigating peptide-membrane dynamics, antimicrobial resistance, and host-pathogen interactions. As a research-use peptide, Omiganan Pentahydrochloride serves as a model compound for exploring the molecular basis of innate immunity and the development of novel antimicrobial strategies.
Antimicrobial Mechanism Studies: Omiganan Pentahydrochloride is widely utilized in mechanistic studies aimed at elucidating how cationic peptides disrupt microbial cell membranes. Researchers employ it to probe the peptide's ability to bind to and permeabilize bacterial and fungal membranes, thus enabling detailed investigations into the biophysical and biochemical processes that underlie peptide-mediated microbial killing. These studies provide critical insights into structure-activity relationships and the design of next-generation antimicrobial agents.
Innate Immunity Research: The compound's mimicry of endogenous host defense peptides makes it an essential tool in the study of innate immune responses. Investigators use Omiganan Pentahydrochloride to model the interaction between antimicrobial peptides and various pathogens, as well as to examine the modulation of immune signaling pathways. Such research helps clarify the roles of cationic peptides in immune surveillance and the mechanisms by which organisms resist infection at the molecular level.
Biofilm Inhibition Assays: Omiganan Pentahydrochloride is employed in research focused on the prevention and disruption of microbial biofilms. Due to its ability to interfere with biofilm formation and persistence, it is used in in vitro assays to assess its efficacy against biofilm-embedded bacteria and fungi. These studies are vital for understanding biofilm resistance mechanisms and for the development of anti-biofilm strategies in industrial, environmental, and biomedical contexts.
Peptide Engineering and Structure-Function Analysis: The unique sequence and activity profile of Omiganan Pentahydrochloride make it a valuable reference in peptide engineering projects. Researchers leverage its structure as a template for designing and synthesizing analogs with enhanced stability, specificity, or activity. Comparative studies involving sequence modifications help delineate critical residues responsible for antimicrobial activity, informing rational design approaches in peptide therapeutics and biomaterials.
Analytical Method Development: The physicochemical properties of Omiganan Pentahydrochloride, including its charge distribution and membrane affinity, render it useful as a standard or probe in analytical method development. It is employed in chromatographic, spectroscopic, and mass spectrometric assays to calibrate detection systems, validate peptide quantification protocols, and optimize separation techniques. Such applications support broader research efforts in peptide analytics and quality control within biochemical laboratories.
The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. The omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.
Sader, H. S., Fedler, K. A., Rennie, R. P., Stevens, S., & Jones, R. N. (2004). Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: spectrum of antimicrobial activity and measurements of bactericidal activity. Antimicrobial agents and chemotherapy, 48(8), 3112-3118.
Omiganan pentahydrochloride is a cidal cationic peptide with a broad antimicrobial spectrum, including yeast, currently in development as a topical agent for the prevention of catheter-associated infections. We evaluated the spectrum and potency of omiganan against pathogens commonly associated with such infections.
Fritsche, T. R., Rhomberg, P. R., Sader, H. S., & Jones, R. N. (2008). Antimicrobial activity of omiganan pentahydrochloride tested against contemporary bacterial pathogens commonly responsible for catheter-associated infections. Journal of antimicrobial chemotherapy.
Ribosomally synthesized antimicrobial peptides have very wide killing spectra and bacterial resistance to these peptides seems to be a rare phenomenon. Indolicidin is a ribosomally synthesized antimicrobial peptide that served as a template to omiganan, which is in development for the prevention of catheter-related bloodstream infections; clinical trials also proved its efficiency against acne vulgaris. Omiganan is the most advanced molecule in the front line of clinical applications of antimicrobial peptides. The mode and site of action of omiganan are not yet settled although its interaction with membranes is known to play a fundamental role. The biochemical and biophysical foundations for the action of indolicidin and its analogues are reviewed in this paper, as well as the clinical application of omiganan. The in vitro efficiency tests and the outcome of clinical trials are addressed. Altogether, despite the very specific use of omiganan as a topical antibiotic, it has the potential of being a pioneer of a new generation of antibiotics that carry the promise of ending the multi-resistance problem.
Melo, M. N., Dugourd, D., & Castanho, M. A. (2006). Omiganan pentahydrochloride in the front line of clinical applications of antimicrobial peptides. Recent patents on anti-infective drug discovery, 1(2), 201-207.
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