Afamelanotide acetate

Afamelanotide is an analog of the peptide hormone alpha-melanocyte stimulating hormone (alpha-MSH), which tends to induce skin tanning.

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CAT#10-101-67
CAS75921-69-6 (net)
Background

Afamelanotide is a synthetic peptide analogue of the naturally occurring alpha-melanocyte stimulating hormone (a-MSH) with potential photoprotective activity. Mimicking the action of a-MSH, afamelanotide stimulates melanocytes to increase the production and release of melanin. Increased melanocyte melanin may protect against ultraviolet radiation (UVR)-initiated cellular DNA damage, oxidation of membrane proteins, and alterations in intracellular signaling processes in epidermal cells. Endogenously, a-MSH is released by skin cells in response to UVR exposure, stimulating melanocytes to produce and release melanin.  >> Read More

Synonyms/Alias(Nle4,D-Phe7)-α-MSH; NDP-MSH; Melanotan 1; CUV1647;Melanotan-1;MT-1;MT1;MT 1;MBJ 05; Afamelanotide acetate; CUV 1647; CUV-1647; CUV1647
Chemical Name(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;acetic acid
M.F/FormulaC78H111N21O19
M.W/Mr.1646.85
SequenceAc-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Labeling TargetMelanocyte-stimulating hormone receptor
ApplicationAfamelanotide is a synthetic analog of α-melanocyte stimulating hormone (α-MSH). It act as a photoprotective agent by inducing skin pigmentation through melanogenesis.
AppearanceSolid powder
Areas of InterestCancer
Cosmetic Peptides & Dermatology
Pituitary & Hypothalamic Hormones
FunctionsUbiquitin protein ligase binding
TargetMelanocyte-stimulating hormone receptor
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