Acetylcysteine Ph. Eur.

Acetylcysteine is also known as N-acetylcysteine or N-acetyl-L-cysteine or NAC. It is the N-acetyl derivative of cysteine. NAC is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the blood stream. Cysteine is a key constituent to glutathione and hence administration of acetylcysteine replenishes glutathione stores. Acetylcysteine can also be used as a general antioxidant which can help mitigate symptoms for a variety of diseases exacerbated by reactive oxygen species (ROS).

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Synonyms/AliasN-Acetyl-L-cysteine; NAC; L-α-Acetamido-β-mercaptopropionic acid; NSC-111180
Chemical Name(2R)-2-acetamido-3-sulfanylpropanoic acid
SequenceOne Letter Code: C
Three Letter Code: Ac-Cys-OH
Labeling TargetGlutathione synthetase; Cystine/glutamate transporter
ApplicationAcute and chronic bronchitis, laryngitis, tracheitis or sinusitisPulmonary complications of cystic fibrosisParacetamol overdose
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AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
ActivityStimulator; Activator
Areas of InterestNeurological Disease
FunctionsMetallopeptidase activity;
Cystine:glutamate antiporter activity
DiseaseBronchiectasis; Amyloidosis; Bronchitis; Cystic fibrosis of the lung
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