Acetylcysteine is also known as N-acetylcysteine or N-acetyl-L-cysteine or NAC. It is the N-acetyl derivative of cysteine. NAC is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the blood stream. Cysteine is a key constituent to glutathione and hence administration of acetylcysteine replenishes glutathione stores. Acetylcysteine can also be used as a general antioxidant which can help mitigate symptoms for a variety of diseases exacerbated by reactive oxygen species (ROS).
CAT# | 10-101-106 |
CAS | 616-91-1 |
Synonyms/Alias | N-Acetyl-L-cysteine; NAC; L-α-Acetamido-β-mercaptopropionic acid; NSC-111180 |
Chemical Name | (2R)-2-acetamido-3-sulfanylpropanoic acid |
M.F/Formula | C5H9NO3S |
M.W/Mr. | 163.2 |
Sequence | One Letter Code: C Three Letter Code: Ac-Cys-OH |
Labeling Target | Glutathione synthetase; Cystine/glutamate transporter |
Application | Acute and chronic bronchitis, laryngitis, tracheitis or sinusitisPulmonary complications of cystic fibrosisParacetamol overdose Show alternative translations |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | Stimulator; Activator |
Areas of Interest | Neurological Disease |
Functions | Metallopeptidase activity; Cystine:glutamate antiporter activity |
Disease | Bronchiectasis; Amyloidosis; Bronchitis; Cystic fibrosis of the lung |
Source# | Synthetic | Solubility | Soluble in DMSO | Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. | Short-term Storage Conditions | Dry, dark and at 0 - 4 °C | Long-term Storage Conditions | -20 °C | Format | neat | Organism | Human | InChI | InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1 | InChI Key | PWKSKIMOESPYIA-BYPYZUCNSA-N | Canonical SMILES | CC(C)C(C)(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13 | Isomeric SMILES | CC(=O)N[C@@H](CS)C(=O)O | BoilingPoint | 407.7±40.0 °C at 760 mmHg | ShelfLife | >2 years if stored properly | Melting Point | 106-108?°C(lit.) |
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