Acetylcysteine is also known as N-acetylcysteine or N-acetyl-L-cysteine or NAC. It is the N-acetyl derivative of cysteine. NAC is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the blood stream. Cysteine is a key constituent to glutathione and hence administration of acetylcysteine replenishes glutathione stores. Acetylcysteine can also be used as a general antioxidant which can help mitigate symptoms for a variety of diseases exacerbated by reactive oxygen species (ROS).
|Synonyms/Alias||N-Acetyl-L-cysteine; NAC; L-α-Acetamido-β-mercaptopropionic acid; NSC-111180|
|Chemical Name||(2R)-2-acetamido-3-sulfanylpropanoic acid|
|Sequence||One Letter Code: C|
Three Letter Code: Ac-Cys-OH
|Labeling Target||Glutathione synthetase; Cystine/glutamate transporter|
|Application||Acute and chronic bronchitis, laryngitis, tracheitis or sinusitisPulmonary complications of cystic fibrosisParacetamol overdose|
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|Purity||>98% (or refer to the Certificate of Analysis)|
|Areas of Interest||Neurological Disease|
|Functions||Metallopeptidase activity; |
Cystine:glutamate antiporter activity
|Disease||Bronchiectasis; Amyloidosis; Bronchitis; Cystic fibrosis of the lung|
|Source#||Synthetic||Solubility||Soluble in DMSO||Shipping Condition||Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.||Short-term Storage Conditions||Dry, dark and at 0 - 4 °C||Long-term Storage Conditions||-20 °C||Format||neat||Organism||Human||InChI||InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1||InChI Key||PWKSKIMOESPYIA-BYPYZUCNSA-N||Canonical SMILES||CC(C)C(C)(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13||Isomeric SMILES||CC(=O)N[C@@H](CS)C(=O)O||BoilingPoint||407.7±40.0 °C at 760 mmHg||ShelfLife||>2 years if stored properly||Melting Point||106-108?°C(lit.)|
|CAT#||Product Name||M.W||Molecular Formula||Inquiry|
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