Linaclotide

Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C; agonist of guanylate cyclase C

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CAT#10-101-161
Chemical Structure
CAS851199-59-2
Synonyms/AliasLinaclotide; Linzess; UNII-N0TXR0XR5X
M.F/FormulaC59H79N15O21S6
M.W/Mr.1526.74
SequenceThree Letter Code: H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2
ApplicationLinaclotide is apeptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 for the treatment in adults of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC).
ActivityAgonist
Biological ActivityLinaclotide is an peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation.
TargetGuanylate Cyclase-C
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