Linaclotide
Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C; agonist of guanylate cyclase C
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| CAT# | 10-101-161 |
| Chemical Structure |  |
| CAS | 851199-59-2 |
| Synonyms/Alias | Linaclotide; Linzess; UNII-N0TXR0XR5X |
| M.F/Formula | C59H79N15O21S6 |
| M.W/Mr. | 1526.74 |
| Sequence | Three Letter Code: H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2 |
| Application | Linaclotide is apeptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 for the treatment in adults of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC). |
| Activity | Agonist |
| Biological Activity | Linaclotide is an peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. |
| Target | Guanylate Cyclase-C |
| Storage | Desiccate at -20°C |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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