Linaclotide

Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C; agonist of guanylate cyclase C

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CAT#	10-101-161
Chemical Structure
CAS	851199-59-2
Synonyms/Alias	Linaclotide; Linzess; UNII-N0TXR0XR5X
M.F/Formula	C59H79N15O21S6
M.W/Mr.	1526.74
Sequence	Three Letter Code: H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2
Application	Linaclotide is apeptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 for the treatment in adults of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC).
Activity	Agonist
Biological Activity	Linaclotide is an peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation.
Target	Guanylate Cyclase-C

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-194	Linaclotide D4	1530.78	C59H75N15O21S6D4	Inquiry
10-101-195	Acylated Linaclotide	1568.76	C61H81N15O22S6	Inquiry
10-101-196	Aspartyl Linaclotide	1527.71	C59H78N14O22S6	Inquiry

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-20	Goserelin Acetate	1269.43	C59H84N18O14	Inquiry
10-101-59	Liraglutide	3751.2	C172H265N43O51	Inquiry
R1574	Octreotide	1019.24	C₄₉H₆₆N₁₀O₁₀S₂	Inquiry
10-101-139	Myrcludex B			Inquiry
10-101-285	Teduglutide	3752.08	C164H252N44O55S	Inquiry
R1847	Sermaglutide	4114	C187H291N45O59	Inquiry
R1961	Carbetocin	988.2	C45H69N11O12S	Inquiry

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Storage	Desiccate at -20°C
Shipping Condition	Room temperature in continental US; may vary elsewhere.