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Linaclotide D4

Isotope labelled Linaclotide. Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C; agonist of guanylate cyclase C

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: 10-101-194

CAS No:851199-59-2 (non-d)

Synonyms/Alias:L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-d4-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine Cyclic (1→6),(2→10),(5→13)-Tris(disulfide); 11: PN: WO2008151257 SEQID: 55 claimed protein-d4; 13: PN: WO2008151257 SEQID: 57 Claimed Protein-d4; 2074: PN: US20090062207 SEQID: 3 Claimed Protein-d4; 40: PN: WO2010065751 SEQID: 55 Claimed Protein-d4; 42: PN: WO2010065751 SEQID: 57 claimed protein-d4; 55: PN: US20100152118 SEQID: 55 Claimed Protein-d4; 55: PN: WO2011069038 SEQID: 55 Claimed Sequence-d4; 55: PN: WO2012037380 SEQID: 55 Unclaimed Protein-d4; 57: PN: WO2011069038 SEQID: 57 Claimed Sequence-d4; 57: PN: WO2012037380 SEQID: 57 Claimed Protein-d4

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C59H75N15O21S6D4
M.W/Mr.
1530.78
Sequence
H–Cys1–Cys–Glu–Tyr–Cys–Cys–Asn–Pro–Ala*–Cys–Thr–Gly–Cys–Tyr–OH
(Disulfide bridge: 1-6; 2-10; 5-13)
Labeling Target
Natriuretic peptide receptor
Application
Linaclotide-d4 is the labeled analogue of a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
Appearance
White to Off-White Solid
Long-term Storage Conditions
DMSO (Slightly), Water (Slightly)
Melting Point
>222°C (dec.)

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