Overview of tetrapeptide-26


Antioxidant effect of peptides 

Peptides have been isolated from the resultant by-products in the past 15 years and suggested as potential safe alternatives to synthetic antioxidants. Bioactive peptides are commonly composed of 3-20 amino acid residues, and their activities depend on amino acid composition and sequence. Several studies have shown that marine-derived peptides might be used as potential antioxidants. The antioxidant activity of peptides has mostly been indicated by their scavenging potency against free radicals in vitro and also by intracellular radical scavenging potency such as DNA oxidation, ROS scavenging, membrane lipid and protein oxidation.

Some studies have indicated that tetrapeptide showed scavenging activities against free radicals with no metal chelating activity, suggesting that free radical quenching was the main antioxidant mechanism in this peptide, which could potentially be useful as a functional cosmetic ingredient.

Functions and usage of Tetrapeptide-26

Tetrapeptide-26 is the synthetic peptide consisting of glutamine, leucine, proline and serine. It is an innovative anti-aging tetrapeptide, designed using advanced molecular biology and inspired by epigenetic science, to boost the expression of clock genes. Specially, it associates with maintenance of expression of CLOCK, BMAL1 and PER1 and leads to a decrease of indued sun burn cells. In addition, it can also repair the damage of UV. Therefore, tetrapeptide-26 is available for after-sun applications.

The store of Tetrapeptide-26

Just like most peptides, tetrapeptide-26 must be stored in a cool, dark and clean place to ensure a shelf life of at least 12 months. For long-term storage, it is recommended to be stored at -20 °C, and the shelf life can be extended to at least 24 months.


1. Pernodet, N. A., Dong, K., Pelle, E., & Yarosh, D. B. (2015). U.S. Patent Application No. 14/019,598.

2. Pernodet, N., Stafa, K., Pelle, E., Dong, K., Goyarts, E., Layman, D., & Corallo, K. (2018). U.S. Patent Application No. 15/794,672.

3. Carullo, A., Palmer Quintano, J., Kassouf, J., Pernodet, N., Collins, D., Layman, D. & Fontanet, O. (2018). U.S. Patent Application No. 15/730,904.

4. Guillemyn, K., Kleczkowska, P., Novoa, A., Vandormael, B., Van den Eynde, I., Kosson, P., ... & Tourwé, D. (2012). In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera. Molecular brain, 5 (1), 4.

5. Nikoo, M., Benjakul, S., Ehsani, A., Li, J., Wu, F., Yang, N., ... & Xu, X. (2014). Antioxidant and cryoprotective effects of a tetrapeptide isolated from Amur sturgeon skin gelatin. Journal of Functional Foods, 7, 609-620.

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