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Acetyl Glutamyl Heptapeptide-3

CAT#
20-101-06
Synonyms/Alias
Snap 8; Acetyl GlutaMyl Octapeptide-3; Acetyl Octapeptide-1; Acetyl Octapeptide-3
CAS No.
868844-74-0
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
M.W/Mr.
1075.16
Molecular Formula
C41H70N16O16S
Description
Acetyl Glutamyl Heptapeptide-3 or Acetyl Octapeptide-1 (or -3) (SNAP-8) is scientifically and reasonablely designed of anti-wrinkle active ingredients of polypeptide. It has a similar role to Areginine Essence and has become one of the most popular raw materials around the world for upscale anti-wrinkle cosmetics.
References
SNAP-8 Solution
INCIName
Acetyl Octapeptide-3
Storage
Common storage 2-8℃, long time storage -20℃.
Functions
Anti-wrinkles caused by the contraction of muscles of facial expression, decreasing neuronal excitability by SNARE complex destabilisation.
Anti-aging which caused by mobile face.removing the deep lines or wrinkles in the forehead or around the eyes area.
It s a safer, cheaper, and milder alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in a very different way.
Dosage
50ppm-800ppm

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SNAP-8 reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes. SNAP-8 is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation. If the SNARE complex is slightly destabilized, the vesicle can not release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.

This article describes a study using a facial serum (C8 Peptide Intensive Treatment, Kinerase ). The facial serum includes several ingredients associated with improvement in the appearance of fine lines and wrinkles and increased barrier function including a neuropeptide. The facial serum also contains kinetin, a cytokinin growth factor with gerontomodulatory effects on cells; SNAP-8, a neuropeptide associated with muscle contraction; beta-glucan, a cell turnover and regenerative extract that is believed to support healthy immunosurveillance; sodium hyaluronate, a humectant and nascent to extracellular matrix; and vitamin C&E formulations and green tea, both of which are antioxidants including polyphenols. This is the first study to assess the efficacy and tolerability of the facial serum in treating fine lines, wrinkles, and signs of photodamage on facial and periocular skin.

Mccall-Perez, F., Stephens, T. J., & Herndon Jr, J. H. (2011). Efficacy and tolerability of a facial serum for fine lines, wrinkles, and photodamaged skin. The Journal of clinical and aesthetic dermatology, 4(7), 51.

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