Arg-Phe-Amide RFamide Related Peptides

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CAT# Product Name M.W Molecular Formula Inquiry
A4701 Metamorphosin A 709.8 C₃₄H₄₇N₉O₈ Inquiry
A4702 Antho-RFamide 488.55 C₂₂H₃₂N₈O₅ Inquiry
A4703 Antho-RWamide I 670.77 Inquiry
A4704 H-Tyr-Gln-Ser-Leu-Arg-Trp-NH2 850.98 Inquiry
A4705 Antho-RWamide II 640.74 Inquiry
A4706 Pyr-Gly-Gly-Leu-Arg-Trp-NH2 697.8 Inquiry
A4707 Antho-RIamide II . HCl 486.01 Inquiry
A4708 Antho-RNamide 585.1 Inquiry
A4709 Anthopleurin-A 5131.8 C₂₂₀H₃₂₆N₆₄O₆₇S₆ Inquiry
A4710 Antho-RPamide I 1015.09 Inquiry
A4711 Antho-RPamide III . HCl 921.54 C₄₂H₆₈N₁₂O₉ · HCl Inquiry
A4712 Antho-RPamide II 929.48 Inquiry


In 1977, Price et al discovered a tetrapeptide in the central nervous system in the macrocallista nimbosa. The peptide is able to exert cardioexcitatory effects with a C-terminal phenylalanine-methionine-arginine-phenylalanine-NH2 (Phe-Met-Arg-Phe-NH2). Later, an increasing number of bioactive peptide with a C-terminal Arg-Phe-Amide (RFamide) have been isolated and identified from many species. Since these compounds have the same structure at the C-terminus: RFamide, they are defined as RFamide peptides, such as GnIH, PQRFa, kisspeptin, PrRP and 26RFa/QRFP. Some RFamide peptides are found in vertebrate animals and they are involved in a wide range of physiological processes, including painful stimulation, arterial blood regulation, food intake control, and regulation of pituitary hormone secretion.

Mechanism of action

The different members of the RFamide peptide family have both central and peripheral functions. Among these RFamind peptides, kisspeptin and gonadotropin-inhibitory hormone (GnIH) have been deeply studied. In recent years, there is increasing evidence that they can directly act on gonadotropin-releasing hormone (GnRH) neurons and play an important role in the regulation of the reproductive axis. PQRFa peptides have been found to function as neurotransmitters or neuromodulators of mammalian opioid systems. In mammals, PrRP peptide acts as a neuroregulator of the central nervous system. In fact, accumulating evidence indicates that the core role of PrRP peptide is to promote energy expenditure and reduce food intake. 26RFamide is able to promote food intake, increase fat mass, plasma leptin, islet and cholesterol.

Application of Arg-Phe-Amide RFamide Related Peptides

There are many members in the RFamide peptide family with different functions. As some RFamide peptides are responsible for food intake and energy expenditure, it is reasonable for them to be useful new therapeutic targets in tackling the worldwide increase in obesity. In the gonads, GnIH and receptors regulate the differentiation and maturation of germ cells through autocrine and paracrine. The research on GnIH will help people understand the reproductive system in human.


  1. Dockray G J . The expanding family of -RFamide peptides and their effects on feeding behaviour[J]. 2004, 89(3):229-235.
  2. Revel F G, Saboureau M, Pévet P, et al. RFamide-related peptide gene is a melatonin-driven photoperiodic gene[J]. Endocrinology, 2008, 149(3):902.
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