Atrial Natriuretic Peptides (ANP/ANF) and Related Peptides

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CAT# Product Name M.W Molecular Formula Inquiry
A17001 ANP (1-11), rat 1224.4 C49H83N20O18S1 Inquiry
A17002 Prepro-ANF (104-116), human 1460.7 C61H113N21O20 Inquiry
A17003 (Cys18)-Atrial Natriuretic Factor (4-18) amide (mouse, rabbit, rat) 1594.84 C64H107N25O19S2 Inquiry
A17004 Des[Gln18,Ser19,Gly20,22,Leu21] ANP (4-23), amide, rat 1594.9 C64H107N25O19S2 Inquiry
A17007 mini-ANP 1829.19 C75H117N27O19S4 Inquiry
A17008 Cardiodilatin (1-16), human 1830.1 C79H120N20O26S2 Inquiry
A17009 Anantin 1871.0 C90H111N21O24 Inquiry
A17011 ANP (11-30), frog 2116.5 C87H138N30O26S3 Inquiry
A17012 Prepro-ANF (104-123), human 2183.6 C94H171N31O28 Inquiry
A17013 Atrial Natriuretic Peptide (4-24), frog 2272.7 C93H150N34O27S3 Inquiry
A17014 (Tyr0)-Prepro-Atrial Natriuretic Factor (104-123), human 2346.8 C103H180N32O30 Inquiry
A17016 Atrial Natriuretic Polypeptide (5-27), human 2404.7 C97H154N34O32S3 Inquiry
A17017 ANP (8-30), frog 2405.7 C97H153N33O33S3 Inquiry
A17018 Atrial Natriuretic Peptide (126-149) (rat) 2542.85 C104H168N38O33S2 Inquiry
A17020 [Tyr0] Atriopeptin II 2549.9 C107H165N35O34S2 Inquiry
A17022 Atrial Natriuretic Peptide (5-28), human 2567.9 C106H163N35O34S3 Inquiry
A17023 Atrial Natriuretic Peptide (126-150) (rat) 2706.02 C113H177N39O35S2 Inquiry
A17024 Atrial Natriuretic Polypeptide (4-28), human 2724.1 C112H175N39O35S3 Inquiry
A17025 ANP (3-28), rat 2862.2 C119H189N43O36S2 Inquiry
A17026 Atrial Natriuretic Peptide (3-28), human 2880.3 C117H187N43O36S3 Inquiry

Introduction

Atrial natriuretic peptide (ANP), also known as atrial natriuretic factor (ANF), plays an essential role in the regulation of blood pressure through the balance of water and salt metabolism. Generally, the common ANP is ANP99-126, which contains 28 amino acids. The synthesis and secretion of ANP are mainly in the atria. The level of ANP in the central ventricle of adults is very low, but ANP has a marked increase in central ventricular tissue in the fetus and newborn. And ANP has also been detected in the central nervous system, lung, adrenal gland, kidney, and vascular tissue. There are three specific receptors for ANP: NPRA, NPRB, NPRC.

Atrial Natriuretic Peptides (ANP/ANF) and Related Peptide

Mechanism of action

ANP is responsible for natriuresis, diuresis, and the regulation of water-salt balance, which is achieved by directly or indirectly altering renal hemodynamics. ANP binds to functional receptors in the medullary collecting duct (MCD) epithelial cells to produce cyclic guanosine monophosphate (cGMP), which controls the amiloride-sensitive sodium channel on the luminal side membrane through the action of cGMP-dependent protein kinase, thereby inhibiting the reabsorption of sodium ions. At the same time, cGMP can inhibit the reabsorption of water by ANP in the collecting tube. In addition to MCD, high concentration of ANP can contract the small arterioles, dilate the afferent glomerular arteriole, and increase the glomerulus filtration rate and filtration fraction, which enhances the sodium excretion of the kidney.

Application of Atrial Natriuretic Peptides (ANP/ANF) and Related Peptides

Hypertension will lead to increased pressure in the atria and ventricle, and may increase in blood volume due to renal drainage and sodium dysfunction, which stimulate the synthesis and release of ANP. ANP is able to lower blood pressure by diuresis, dilating of blood vessels and reducing peripheral resistance. It is found that the level of ANP are significantly increased in cardiovascular diseases such as hypertension, indicating that the synthesis and secretion of ANP may be a compensatory and protective response in a pathological state.

References

  1. Baxter J D, Lewicki J A, Gardner D G. Atrial Natriuretic Peptide[J]. Nature Biotechnology, 1988, 37(6):529-546.
  2. Rydén M, B?ckdahl J, Petrus P, et al. Impaired atrial natriuretic peptide-mediated lipolysis in obesity[J]. Int J Obes, 2016, 40(4):714-720.
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