Melanocyte-Stimulating Hormone (MSH) and MSH-Sequences

* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

Online Inquiry

CAT# Product Name M.W Molecular Formula Inquiry
M09001 a-MSH, amide C77H109N21O19S1 Inquiry
M09002 a-MSH, Free Acid C77H108N20O20S1 Inquiry
M09003 [Des-Ac] a-MSH, amide C75H107N21O18S1 Inquiry
M09004 g-MSH C74H99N21O16S1 Inquiry
M09005 g-1-MSH, amide C72H97N21O14S1 Inquiry
M09006 MSH Release Inhibiting Factor, amide C13H24N4O3 Inquiry
M09007 b-MSH, porcine C98H138N26O29S1 Inquiry
M09009 [Lys0]-γ-1-MSH (41-58), amide Inquiry
M09010 Melanocyte Associated Antigen gp 100 (17-25) Inquiry
M09011 Melanotropin-Potentiating Factor, MPF C13H24N4O3 Inquiry
M09012 RAB38/NY-MEL-1 (50-58) Inquiry


α-melanocyte stimulating hormone (α-MSH) is a family member of endogenous neuropeptide-melanocortin, derived from proopiomelanocortin (POMC) and secreted from the brain and pituitary gland. Serum α-MSH may act as a protective biomarker for non-traumatic osteonecrosis of the femoral head (ONFH). Systematic application of α-MSH serving as an adjunctive therapy for treating non-traumatic ONFH deserves further investigation. γ-Melanocyte stimulating hormone (γ-MSH) is an endogenous agonist of the melanocortin 3-receptor (MC3R). Previous studies have shown that multiple melanocortin peptides are present in osteoblastic like cells, which indicate that α-MSH might have an effect on osteoblast cells to regulate bone development and maturation.

Mechanism of action

α-MSH exerts its function via its cell surface receptors, named melanocortin receptors. Melanocortin receptors are G-protein coupled receptors, including MC-1R, MC-2R, MC-3R, and MC-4R. MC-1R is specifically expressed in the majority of melanomas, a leading cause of death related to skin cancers. Recent studies have proven that α-MSH protects the damage from dexamethasone on osteoblast-mediated by melanocortin receptors. These findings indicate that, α-MSH most likely acts directly as osteoblast or other related progenitor cells to participate in bone development and metabolism. α-MSH activates MC1R downstream ERK1/2 signaling to promote osteogenic differentiation and mineralization of osteoblast cells.

Application of Melanocyte-Stimulating Hormone (MSH) and MSH-Sequences

Due to the natural derivation of α-MSH and its effect on osteoblast differentiation based on the present study, α-MSH may be a potential candidate for a new generation of anti-osteoporosis drugs. Meanwhile, MC1R may provide a good target for designing therapeutic agents. Besides, α-melanocyte-stimulating hormone (α-MSH) has been characterized as a novel angiogenesis inhibitor. Based on the α-melanocyte-stimulating hormone sequence, MC-1R-targeted peptides have been studied for melanoma imaging, predominately for use with single-photon emission computed tomography, with few attempts made for positron emission tomography (PET). Over the years, different classes of α-MSH derivatives were developed and have seen successful usage for melanoma imaging.


  1. Lei Wang., Jian Cheng., Zhen Hua., Mingming Liu., Haiyan Xu., Yong Ma., Guicheng Huang., &Guoqing Mao. (2019). α-melanocyte stimulating hormone (α-MSH) promotes osteoblast differentiation of MC3T3-E1 cells. European Journal of Pharmacology, 844(5), 1-8.
  2. Eerola K., Virtanen S., Vähätalo L., Ailanen L., Cai M., Hruby V., Savontaus M., &Savontaus E. (2018). Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice. Journal of Endocrinology, 239(1), 19-31.
  3. Zheng Mao., Gang Liu., Jing-Jie Chen., Dan Liu., Min-Peng Xu., Chang Zhao., Hai-Tao Yang., Yong-Bin Yue. (2017). Serum α-melanocyte-stimulating hormone may act as a protective biomarker for non-traumatic osteonecrosis of the femoral head. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 55(4):453-460.
  4. Chengcheng Zhang., Zhengxing Zhang., Kuo-Shyan Lin., Joseph Lau., Jutta Zeisler., Nadine Colpo., David M. Perrin., & Francois Benard. (2018). Melanoma Imaging Using 18F-Labeled α-Melanocyte-Stimulating Hormone Derivatives with Positron Emission Tomography. Molecular pharmaceutics, 15, 2116−2122.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Customer Support & Price Inquiry

Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!

The mammalian precursor gene proglucagon, which contains the glucagon sequence together with two structurally related glucago ...

Ganirelix, a synthetic decapeptide compound, is a gonadotrophin-releasing hormone (GnRH) antagonist preparation ...

What is abaloparatide? Abaloparatide (formerly known as BA058) is an investigational analog of human PTHrP (1-34) being devel ...

 Compstatin is a 13-residue cyclic peptide (Ile1-Cys2-Val3-Val4-Gln5-Asp6-Trp7-Gly8-His9-His10-Arg11-Cys12-Thr13- ...

 Phosphoramidon is a kind of thermolysin inhibitor isolated from a culture filtrate of streptomyces. It has prove ...

Quick Inquiry
Contact Us



Tel: |




Copyright © 2024 Creative Peptides. All rights reserved.