Neuropeptide Y (NPY), Analogs and Fragments

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CAT# Product Name M.W Molecular Formula Inquiry
N05001 (Pro30,Tyr32,Leu34)-Neuropeptide Y (28-36) 1206.46 C57H91N17O12 Inquiry
N05002 Ac-[Leu28,31] Neuropeptide Y (24-36), human 1787.1 C81H131N27O19 Inquiry
N05003 Neuropeptide Y (22-36), porcine 1903.2 Inquiry
N05004 Neuropeptide Y(18-36), porcine 2456.9 Inquiry
N05005 Neuropeptide Y (1-24) amide (human, rat) 2656.87 C116H170N30O40S Inquiry
N05006 Neuropeptide Y (1-24), human 2657.1 C116H170N30O40S1 Inquiry
N05007 (Leu31,Pro34)-Neuropeptide Y (13-36) (human, rat) 2969.42 C134H206N39O35S Inquiry
N05008 Neuropeptide Y (13-36) (porcine) 2982.4 C135H209N41O36 Inquiry
N05009 Neuropeptide Y (13-36), human 3000.5 C134H207N41O36S1 Inquiry
N05010 Neuropeptide Y (3-36), porcine 3993.4 Inquiry
N05011 Neuropeptide Y (3-36), human 4011.5 C175H269N53O54S1 Inquiry
N05012 Neuropeptide Y (2-36) (porcine) 4090.53 C181H278N54O55 Inquiry
N05013 Neuropeptide Y (2-36) (human, rat) 4108.6 C180H276N54O55S1 Inquiry
N05015 Pancreatic Polypeptide Fragment 1-17-[Ala31, alpha-Aminoisobutryl32]-Neuropeptide Y Fragment 18-36 4124.7 C185H280N54O52S1 Inquiry
N05016 (Gly1,Ser3.22,Gln4.34,Thr6,Arg19,Tyr21,Ala23.31,Aib32)-P 4207.73 C183H281N57O54S2 Inquiry
N05017 Pancreatic Polypeptide (1-17)-(Ala31,Aib32)-Neuropeptide Y (18-36) (human) 4209.76 C189H287N55O53S Inquiry
N05018 [Pro34] Neuropeptide Y, porcine 4222.7 C190H286N54O56 Inquiry
N05019 [Leu31,Pro34] Neuropeptide Y (1-36), porcine 4222.7 C190H286N54O56 Inquiry
N05020 [Pro34] Neuropeptide Y (1-36), human 4240.8 C189H284N54O56S1 Inquiry
N05021 [Leu31,Pro34] Neuropeptide Y, human 4240.8 C189H284N54O56S1 Inquiry

Introduction

Neuropeptide Y is an amidated 36 amino acid peptide that is located in synaptic particles. At the same time, it can release in response to the synaptic transmission. Studies show that it is widely distributed in the central and peripheral mammalian nervous systems. Neuropeptide Y exerts its potent effects on many targets of the central nervous system and the periphery. This peptide acts as a vasoconstrictor and is capable of enhancing the action of other pressors, but also inhibits the release of sympathetic nerve fiber emitters. In addition, the mature neuropeptide Y protein is one of the most abundant neuropeptides in the central nervous system and has an amidated C-terminal residue.

Mechanism of action

Neuropeptide Y a 36-mer neuromodulator involves in the central and peripheral control of blood pressure and in feeding behavior and obesity and binds to the receptors with nanomolar affinity. The different receptor subtypes are located in various tissues, in the central nervous system, and in the periphery. Stress exaggerates diet-induced obesity through a peripheral mechanism that is mediated by neuropeptide Y in the abdominal white adipose tissue. For example, stressors that are exposed to cold or aggressiveness cause neuropeptide Y to be released from the sympathetic nerves, which in turn regulates the role of neuropeptide Y and its Y2 receptor in abdominal fat in a glucocorticoid-dependent manner. This positive feedback response of neuropeptide Y results in the growth of abdominal fat.

Application of Neuropeptide Y

Neuropeptide Y has been shown to have an effect on emotional behavior and alcohol intake using a rodent model. Some studies showed that administration of neuropeptide Y to the paraventricular nucleus of the rat repeatedly produced a feeding behavior that leads to obesity and leads to overeating in diabetic animals. In addition, neuropeptide Y appears to affect anxiety and memory. There is increasing evidence show that in preclinical and clinical neuropeptide Y is involved in emotional disorders such as depression. In addition, neuropeptide Y has a role in alcohol intake, dependence, and withdrawal.

References

  1. Wieland, H. A., Willim, K., & Doods, H. N. (1995). Receptor binding profiles of NPY analogues and fragments in different tissues and cell lines. Peptides, 16(8), 1389-1394.
  2. Thorsell, A. (2007). Neuropeptide Y (NPY) in alcohol intake and dependence. Peptides, 28(2), 480-483.
  3. Abid, K., Rochat, B., Lassahn, P. G., Stocklin, R., Michalet, S., Brakch, N., ... & Grouzmann, E. (2009). Kinetic study of neuropeptide Y (NPY) proteolysis in blood and identification of NPY3-35, a new peptide cleaved by plasma kallikrein. Journal of Biological Chemistry, jbc-M109.
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