Effect of GRF (Human) Acetate on Growth Hormone
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Effect of GRF (Human) Acetate on Growth Hormone

2018-11-16

Introduction

Growth hormone releasing factor (GRF) (human) acetate is an acetate salt of an amidated synthetic 29-amino acid peptide (GRF (1–29) NH2), which is designed to make sure the stability of GRF in vitro. Obviously, the essence of GRF acetate is GRF. As a result, there are several synonyms like somatoliberin (human), growth hormone-releasing hormone (human) and something else for both GRF acetate and GRF. It is well recognized that GRF acetate, with the sequence that is H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2, is capable of stimulating the synthesis and secretion of growth hormone from the anterior pituitary.

Pharmacologic action

GRF acetate, an acetate salt form of GRF, has almost the same mechanism of action as GRF. GRF is a 44-amino acid peptide hormone, as well as one of the endogenous hormones, which is produced in the arcuate nucleus of the hypothalamus. The behavior route of GRF in human body has been discovered for a long time. First of all, GRF is released from neurosecretory nerve terminals of the arcuate neurons in the hypothalamus. And then, GRF is brought to the anterior pituitary gland with the action of the hypothalamo-hypophyseal portal system. In the end, GRF stimulates GRF receptor to provoke the synthesis and secretion of growth hormone from the anterior pituitary.

Function

For the past few years, GRF acetate has been mainly used in the field of regenerative medicine. As a matter of fact, GRF acetate takes effect by means of GRF. It is generally considered that GRF, a hypothalamic hormone, mainly possesses a function of promoting the synthesis and secretion of growth hormone from the anterior pituitary. That is to say, GRF obtain the abilities of growth hormone such as resist aging, promote growth and some others indirectly.

Pharmacokinetics and metabolism

GRF acetate is a synthetic drug, the effective ingredient of which in human body is GRF. GRF is released in a pulsatile manner, which provokes growth hormone into releasing in the similar way and then participates indirectly in the regulation of protein and fat metabolism.

References:

Harvey S, Gineste C, Gaylinn B D. Growth hormone (GH)-releasing activity of chicken GH-releasing hormone (GHRH) in chickens[J]. Gen Comp Endocrinol, 2014, 204(8):261-266.

Petersenn S, Rasch A C, Heyens M, et al. Structure and regulation of the human growth hormone-releasing hormone receptor gene.[J]. Molecular Endocrinology, 1998, 12(2):233-247.

Estévez M D, Alfonso A, Vieytes M R, et al. Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release[J]. Inflammation research : official journal of the European Histamine Research Society. [et al.], 1995, 44(2):87-91.

Nakagawa J, Mori H, Maeda T, et al. Dynamics of secretory granules in somatotrophs of rats after stimulation with growth hormone-releasing factor: a stereological analysis.[J]. Cell & Tissue Research, 1995, 282(3):493-501.

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