Introduction PT-141, also called as Bremelanotide, is a derivative for Melanotan 2 (M2). Unlike M2, PT-141 lacks C-terminal amide molecules. PT-141, a synthetic cyclic hepta-peptide lactam derivative

Thymosin Thymosin is a hormone secreted from the thymus. This is the reason why it is named Thymosin. But most are now known to be present in many other tissues. Its primary function is to stimulate t

Introduction The pancreatic polypeptide (PP) family includes three endogenous peptides: PP, peptides-neuropeptide Y (NYP) and peptide YY (PYY)-all of which have been localized to both central and peri

Introduction Glutathione (γ-Glu-Cys-Gly, GSH) is the most abundant antioxidant in animal tissues, at 0.1-10 mM, as well as in plants and microorganisms. Glutathione exists in two different forms: red

Discovery and Structure Calcitonin, also called thyrocalcitonin, a protein hormone synthesized and secreted in humans and other mammals primarily by parafollicular cells (C cell) in the thyroid gland.

Basic information Desmopressin is a synthetic analogue of the antidiuretic hormone vasopressin used in the treatment of central diabetes insipidus and nocturnal ensuresis and as a haemostatic agent. T

The Discovery of Somatostatin Somatostatin (SS) is an endogenous peptide hormone isolated, purified and characterized in 1973 from almost 500,000 sheep hypothalamic fragment. The molecule is a 14-amin

Glucagon-like peptide-1 (GLP-1) and glucose-depended insulinotropic polypeptide (GIP) are the two peptides that have been confirmed to act as incretin hormones to date. GIP was the first incretin horm

Octreotide, a long-acting structural derivative of somatostatins, is a synthetic peptide analog of somatostatin with the same pharmacologic effects. Octreotide is a cyclic octapeptide containing two D

Brief information of bombesin Bombesin is a tetradecapeptide which was originally isolated from Bombina Bombina frog skin then later found to have a wide distribution and range action in mammals. Bomb

Overview of the kinin system Kinins are peptide hormones that are formed as part of the kinin-kallikrein system (KKS). kinin peptides are potent vasodilators and also promote diuresis and natriuresis.

Peptides are the ideal drug molecules because of their high affinity, high selectivity, low toxicity, and easy synthesis. Scientists have also developed novel peptide drugs that can treat multiple dis

5. Synthetic Peptides Targeting CD36 Attenuate Lipopolysaccharide-Induced InflammationSynthetic amphipathic helical peptides (SAHPs) designed as apolipoprotein A-I mimetics are known to bind to class

Trimetazidine is a partial fatty acid oxidation inhibitor that inhibits 3-ketoacyl CoA thiolase, one of the enzymes of fatty acid ß-oxidation. This results in an increase in glucose oxidation. In pres

Since the discovery of Substance P (SP) in the early 1930s, its pharmacological actions have been extensively studied. SP has been identified as a neurotransmitter and neuromodulator in the central ne

Brief information of orexin peptide The past several years have provided important insights into the physiological significance of the central orexin system. The orexin peptides, orexin-A and orexin-B

Insulin was discovered by Banting and Best in 1921. Soon afterwards manufacturing processes were developed to extract the insulin from porcine and bovine pancreas. From 1921 to 1980, efforts were dire

Glucagon is a 29-amino acid peptide hormone that is synthesized in pancreatic α cells from the proglucagon precursor by prohormone convertase 2 (PC2). The primary structure of glucagon is identical in

The mammalian precursor gene proglucagon, which contains the glucagon sequence together with two structurally related glucagon-like peptides, glucagonlike peptides-1 and -2 (GLP-1 and GLP-2), is found

What is abaloparatide? Abaloparatide (formerly known as BA058) is an investigational analog of human PTHrP (1-34) being developed for the treatment of osteoporosis. The amino-acid sequence of abalopar

Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!

 Jingzhaotoxin-III (β-TRTX-Cj1α) is a kind of sodium channel gating modifier which is from the tarantula Chilobra ...

 Tertiapin-Q (TPN-Q) is a small compact protein that contains twenty-one amino acids, which derived from bee veno ...

 The serine/threonine kinase Pim-1 plays an important role in cell cycle progression and apoptosis inhibition, re ...

 Gonadorelin is a synthetic GnRH, a peptide compound, and a decapeptide whose structure is exactly the same as th ...

IGF-1 IGF-1 is a single chain peptide consists of 70 amino acids in four domains, B, C, A and D. The A- and B-domains are str ...

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