Function of acetyl glutamyl heptapeptide-3 in skin



Acetyl Glutamyl Heptapeptide-3, named SNAP-8, Acetyl GlutaMyl Octapeptide-3, Acetyl Octapeptide-1, Acetyl Octapeptide-3 and anti-wrinkle oligopeptide, a cosmetic peptide, is an extended analog of hexapeptide aquillin, and its molecular structural formula is as shown in Fig.1. Since Acetyl Glutamyl Heptapeptide-3 is a scientifically and rationally designed anti-wrinkle active raw material peptide based on modern biochemical mechanism, Acetyl Glutamyl Heptapeptide-3 has become a popular cosmetic material for anti-wrinkle in the world. And It is also claimed in all high-end cosmetics series that anti-wrinkle oligopeptide is applied for anti-wrinkle.

The molecular structural formula of Acetyl Glutamyl Heptapeptide-3

Fig.1 The molecular structural formula of Acetyl Glutamyl Heptapeptide-3

Mechanism of anti-wrinkle

Acetyl Glutamyl Heptapeptide-3 is a neuropeptide associated with muscle contraction. SNAP-8 mimics the N-terminus of SNAP-25, which competes with SNAP-25 for position in the SNARE (soluble NSF attachment protein receptor) complex, thereby regulating its formation. If the SNARE complex is slightly destabilized, the vesicle can't efficiently release neurotransmitters and causing the attenuation of muscle contraction, preventing the formation of lines and wrinkles, which not only can makes the skin relax and reduces the expression lines but also has an excellent properties of smooth the skin and rapid wrinkle.

Efficacy and application

The Acetyl Glutamyl Heptapeptide-3, as a cosmetic raw materials, plays an important role in our life. And it has many magical effects, such as it can be as an ingredient associated with the serum, emulsion, and gel in the cosmetic formula to decrease the appearance of fine lines and wrinkles and increase in stratum corneum barrier function, and importantly, it can reduces the depth of wrinkles caused by facial muscle contractions, especially around the forehead and around the eyes. Furthermore, compared with the botulinum toxin type A (a well-known product for wrinkle and beauty), the Acetyl Glutamyl Heptapeptide-3 is more safer, cheaper and milder, and can be applied topically, such as in a skin cream, rather than by injection, which may attract more attention of researchers and expected to be applied in the cosmetic filed.


1. Lin AT-L. Basic pharmacology of botulinum toxin in lower respiratory tract infection. Tzu Chi Med J. 2007, 19 (3): 109–114.

2. Guitierrez LM, Viniegra S, Rueda J, V. Ferrer-Montiel A, M. Canaves J, Montal M. Peptide that mimics the C-terminal sequence of SNAP-25 inhibits secretory vesicle docking in chromaffin cells. J Biol Chem. 1997, 272 (5): 2634-2639.

3. Mccallperez F, Stephens T J, Jr J H H. Efficacy and Tolerability of a Facial Serum for Fine Lines, Wrinkles, and Photodamaged Skin. Journal of Clinical and Aesthetic Dermatology, 2011, 4(7):51-54.

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