Function of trifluoroacetyl tripeptide-2 in human skin


An overview of trifluoroacetyl tripeptide-2  

Peptides are chains of amino acids joined by peptide bond. Peptides are mostly involved in protein regulation, angiogenesis, cellproliferation, melanogenesis, cell migration and inflammation. In past few decades, bioactive peptides have been widely used in cosmetic industry. Peptides need to have low molecular weight (<500 Da), high stability, solubility to ease peptide diffusibility across the epidermal layers. Over the years, science has developed small, stable, and synthetic peptide fragments which activate collagen production and reduce facial wrinkles and pigmentation. Trifluoroacetyl Tripeptide-2 (Sequence: TFA-Val-Try-Val-OH) is a synthetic tripeptide, designed as a matrix metalloproteinase and an elastase inhibitor. The in vitro studies were conducted to assess the effects of trifluoroacetyl-tripeptide-2 (TT2) on ECM protection, on the synthesis of proteoglycans in cell-matrix interactions, and on the synthesis of progerin in mature human normal fibroblasts, a protein recently identified as a co-inducer of cellular senescence. The results show that trifluoroacetyl-tripeptide-2 has the broader anti-aging properties. It can decrease progerin synthesis, increase proteoglycan production and contract collagens, therefore it can reduce wrinkles and increase firmness of the tissue. In addition, it was evaluated in two in vitro split face studies about its anti-wrinkle, anti-sagging and skin firmness effects. According to the studies, trifluoroacetyl-tripeptide-2 has progressive effects on wrinkles, firmness, elasticity and sagging.

The function of trifluoroacetyl tripeptide-2

As a cosmetic ingredient, trifluoroacetyl-tripeptide-2 has excellent emulsifying, dispersing, antistatic, smearing and wetting ability. It can avoid the damage of residual substances to the skin's natural protective layer. Therefore, trifluoroacetyl-tripeptide-2 is important for controlling the phenomenon of aging.


1. LOING, E., SUERE, T., & LAMARQUE, E. (2012). Trifluoroacetyl-tripeptide-2 to target senescence for anti-aging benefits. Cosmetics and toiletries, 127 (4).

2. Das, M., Kundu, D., Singh, J., Rastogi, A., Mukherjee, G., & Chatterjee, A. Rejuvenation of Metabolic Cascades for Controlling Aging through Bioactive Compounds: A Review. J Nutri Food Sci Forecast. 2018; 1 (1), 1003.

3. Bezivin, C. (2017). U.S. Patent Application No. 15/124,717.

4. Anton, J. M. G., Montiel, A. V. F., Serraïma, C. C., GONZÁLEZ, R. D., & Puche, J. C. (2017). U.S. Patent No. 9,725,483. Washington, DC: U.S. Patent and Trademark Office.

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