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Hexapeptide-9

CAT#
CPC1614
Synonyms/Alias
Collagen peptide III
CAS No.
1228371-11-6
M.W/Mr.
582.61
Molecular Formula
C24H38N8O9
Description
Hexapeptide-9 promotes the synthesis of dermal collagen, the regeneration of dermal-epidermal junction and the skin differentiation.
References
Collaxyl IS
INCIName
Hexapeptide-9
Storage
Common storage 2-8℃, long time storage -20℃.
Functions
Hexapeptide-9 has significant wrinkle reduction and skin reparing effects.

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Hexapeptide-9 is a synthetic peptide containing Glutamine, Glycine and Proline residues.

For example, linear hexapeptide 9 was prepared by removing the –Troc protection on 3 to afford 7 and appending the glycine-pyrrole side chain 5 to give 8. After -Fmoc removal, coupling to 4 afforded the desired branched hexapeptide 9, with only the final cyclization and protection group removal remaining. However, compound 9 proved highly unstable and did not succumb to cyclization.

Curzon, S. S., Garcia, J. M., & Konopelski, J. P. (2015). Total synthesis of nominal cyclocinamide B and investigation into the identity of the cyclocinamides. Tetrahedron letters, 56(23), 2991-2994.

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