Palmitoyl Hexapeptide-12, a natural powerful antiager


Introduce of lipopeptide 

Lipopeptide (peptidolipid), also known as acylpeptide, is composed of hydrophilic peptide bond and lipophilic aliphatic hydrocarbon chain. It has good surface activity, can increase the bioavailability of hydrophobic hydrocarbons and stimulate the biodegradation of hydrocarbons. Because it can combine with heavy metals, the heavy metals can be removed from contaminated soils and sediments. So it is an important class of biosurfactants. It also has special biological activities, such as increasing the activity of urokinase, preventing blood from clotting. Most lipopeptides also have an antimicrobial effect, so also known as antibiotics. Due to its special chemical composition and amphiphilic molecular structure, lipopeptide biosurfactants have important application prospects in the fields of medicine, cosmetics and microbial oil recovery.

Effect and application of Palmitoyl hexapeptide-12

Palmitoyl Hexapeptide-12 (Sequence: Pal-Val-Gly-Val-Ala-Pro-Gly), also known as palmitoyl oligopeptide, is a lipopeptide molecule in biopeptide-EL, and a signal peptide. Unlike water-soluble peptides, palmitoyl Hexapeptide-12 is highly biocompatible with skin's natural structure. It boosts cell's natural productivity level and is considered to be one of the most natural powerful antiagers.

Palmitoyl hexapeptide-12 is a signal peptide belonging to the Matrikine series, which is particularly involved in repairing age-related skin damage and promoting dermal fibroblast migration, proliferation, and matrix macromolecular synthesis (eg, elastin, collagen, etc.). It provides support for the skin. It also induces fibroblasts and monocytes to specific locations for wound repair and tissue renewal. Studies have shown that it can reduce the production of interleukin-6 (IL-6) in key skin cells, keratinocytes and fibroblasts. As we all know, IL-6 is a molecule, which can promote the production of inflammation and lead to faster degradation of the skin matrix, resulting in more wrinkles, poor skin firmness and elasticity. Palmitoyl hexapeptide-12 can greatly slow down the degradation of the skin matrix, and may also stimulate its replenishment by reducing the levels of IL-6 and possibly other inflammation mediators.

In conclusion, as an active agent of cosmetic, palmitoyl hexapeptide-12 may be used individually or in combination with one or more other peptides, such as

palmitoyl tetrapeptide-7, which synergistically and significantly increases the amount of collagen and hyaluronic acid in the skin.


1. Pernodet, N., Corallo, K., Layman, D., & Collins, D. (2018). U.S. Patent No. 9,877,916. Washington, DC: U.S. Patent and Trademark Office.

2. Lee, M., Park, H., Jeon, S. W., Bang, J., Chung, K. Y., Choi, D. W & Lim, K. M. (2015). Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12. Archives of dermatological research, 307(3), 249-257.

3. Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.

4. Vanaman Wilson, M. J., Bolton, J., & Fabi, S. G. (2017). A randomized, single‐blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face. Journal of cosmetic dermatology, 16(2), 217-222.

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