Pentapeptide-18 is a synthetic peptide composed of five amino acids designed for use in cosmetic formulations targeting the appearance of expression lines and wrinkles. By supporting skin conditioning and smoothing, it is suitable for anti-aging skincare products such as serums, creams, and lotions. Pentapeptide-18 is compatible with a wide range of formulation types and demonstrates stability under typical cosmetic processing conditions. Recommended for inclusion in facial care and targeted treatment applications.
Mechanism of Action (MOA)
Pentapeptide-18 is a synthetic neuropeptide that mimics the N-terminal end of SNAP-25, a substrate of the SNARE complex involved in neurotransmitter release. By competitively inhibiting SNAP-25's interaction within the SNARE complex, Pentapeptide-18 modulates calcium-dependent neuronal exocytosis. This action helps to attenuate the release of neurotransmitters at the neuromuscular junction, leading to a relaxation effect on facial muscle contractions at the cellular signaling level.
Pentapeptide-18 is suitable for incorporation into a variety of cosmetic formulations targeting daily skincare routines.
- Facial serums and concentrates- Moisturizing creams and lotions- Eye contour gels and creams- Sheet masks and leave-on treatments- Makeup primers and foundations- Overnight skin treatments
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Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
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