Palmitoyl Hexapeptide-12 is a synthetic peptide composed of six amino acids linked to a palmitic acid chain to enhance skin penetration. Recognized for its role in cosmetic formulations, it supports the appearance of smoother, more resilient skin by contributing to the maintenance of the skin's extracellular matrix. Suitable for use in anti-aging, firming, and skin conditioning products, it is compatible with a wide range of topical applications.
CAT No: CPC1628
CAS No:171263-26-6
Synonyms/Alias:Palmitoyl hexapeptide-12;171263-26-6;2-((S)-1-((2S,5S,11S)-5,11-Diisopropyl-2-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctacosan-1-oyl)pyrrolidine-2-carboxamido)acetic acid;Palmitoyl hexapeptide-12 [INCI];N-Palmitoyl-val-gly-val-ala-pro-gly;Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-;HO4ZT5S86C;2-[[(2S)-1-[(2s)-2-[[(2s)-2-[[2-[[(2s)-2-(hexadecanoylamino)-3-methylbutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid;Pal-VGVAPG (acetate);Lipopeptide;Palmitoyl hexapeptide 12;Palmitoyl hexapeptide-12?;UNII-HO4ZT5S86C;SCHEMBL23230092;JFSQSDAOQLNSQI-DTBJPNGVSA-N;C38H68N6O8;DTXSID401018159;AKOS027321446;DA-75030;DS-11734;HY-66015;CS-0005655;Q27280026;palmitoyl-L-valylglycyl-L-valyl-L-alanyl-L-prolylglycine;2-((S)-1-((2S,5S,11S)-5,11-Diisopropyl-2-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctacosan-1-oyl)pyrrolidine-2-carboxamido)aceticacid;
Mechanism of Action (MOA)
Palmitoyl Hexapeptide-12 is a signal peptide conjugated with a palmitoyl chain to enhance skin affinity. It interacts with cellular receptors in the extracellular matrix, supporting the communication between dermal fibroblasts and surrounding matrix proteins. This peptide is known to modulate cell signaling pathways associated with extracellular matrix components, including fibronectin and collagen, thereby contributing to the maintenance of skin's structural integrity and overall appearance.
Palmitoyl Hexapeptide-12 is a versatile peptide suitable for various cosmetic formulations.
- Can be incorporated into facial serums for daily skin care routines- Suitable for use in anti-aging creams and lotions- Compatible with eye contour products- May be added to hydrating masks and overnight treatments- Appropriate for use in lightweight emulsions and gels- Can be blended into targeted treatment concentrates
2. TMEM16F and dynamins control expansive plasma membrane reservoirs
4. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
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