Basic Fibroblast Growth Factor, Human

Human FGF-b is a 17.2 kDa protein containing 154 amino acid residues. The Fibroblast Growth Factor-basic (FGF-b) is a heparin binding growth factor which stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal & endothelial cells.

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Basic fibroblast growth factor (bFGF) is an important mitogen and neurotrophic factor that binds and signals through the high-affinity receptor, fibroblast growth factor receptor 1 (FGFR1). However, only a limited amount of information is available concerning the molecular forms and anatomical distribution of fibroblast growth factors (FGFs) in the normal human brain.

Synonyms/AliasBasic fibroblast growth factor
FunctionsBasic fibroblast growth factor presents in basement membranes and the subendothelial extracellular matrix of blood vessels. It stays membrane-bound as long as there is no signal peptide, and can be used in wound healing as a cosmeceutical.
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