Palmitoyl Tripeptide-1


Palmitoyl Tripeptide-1 is also called Part of Matrixyl 3000. Palmitoyl Oligopeptide and Pal-GHK are believed to be able to stimulate collagen production in the skin, since more collagen means fewer wrinkles and younger skin, so they are often used in cosmetic products.


Palmitoyl wheat protein hydrolysate is a wheat bioprotein that has a rapid relaxing mechanical action to smooth out facial expression wrinkles and has a long term redensifying biological effect on dermal and epidermal cells, thereby lastingly filling deep lines and wrinkles.


Tripeptide refers to a peptide consisting of three amino acids joined by peptide bonds. Tripeptide-1 is a proprietary, specialized molecule that is a synthetic peptide containing three amino acid residues-glycerine, histidine, and lysine. An example of a carrier peptide is the tripeptide glycyl-L-histidyl-L-lysine (GHK), which has been shown to facilitate copper uptake of cells and to stimulate fibroblast collagen synthesis. Additional effects of GHK include dermal remodeling by increasing levels of MMP-2 and MMP-2 mRNA and increasing levels of tissue inhibitors of metalloproteinase 1 and 2, increases in type I collagen and glycosaminoglycans,48 and increases in dermatan sulfate and cell layer-associated heparin sulfate.

The study and function of Palmitoyl Tripeptide-1

The Palmitoyl Tripeptide-1 is suggested to act on TGFβ to stimulate fibrillogenesis. It is used in anti-wrinkle skincare and make-up products. In a blind randomized clinical study, 28 volunteers applied a cream containing the active compound palmitoyltripeptide-1 to half of the face and one of the forearms while applied a placebo cream to the other half of the face and other forearm twice a day. This experiment confirmed the anti-wrinkle effects of Palmitoyl Tripeptide-1, which can redue the depth, volume and density of wrinkles, reduce skin roughness, complexity and the area occupied by deep wrinkles, and increases skin tone.


1. Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International journal of cosmetic science, 31(5), 327-345.

2. Zhang, L., & Falla, T. J. (2009). Cosmeceuticals and peptides. Clinics in dermatology, 27(5), 485-494.

3. Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.

4. Vanaman Wilson, M. J., Bolton, J., & Fabi, S. G. (2017). A randomized, single‐blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face. Journal of cosmetic dermatology, 16(2), 217-222.

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