The Usage of Pentapeptide-31


Introduction of skin aging 

Skin aging is an obvious external manifestation of the natural process occurring in tissues and organs throughout the body. In young and healthy skin, the level of collagen is high, the skin looks young and glowing, and the proteolytic system can effectively prevent the accumulation of damaged proteins in cells and in ECM. While in aged skin, collagen is depleted, skin muscles stop providing support, leading to lines and wrinkles and sagging skin, and the skin is damaged, the skin system becomes inefficient and is easily "clogged" by some protein fragments.

Therefore, we need some ways to prevent aging. As we all know, various peptides affect the aging process by modulating collagen homeostasis. The use of peptides has now been extended as cosmeceuticals, which can give skin a filling effect without painfully resorting to surgical procedures.

An overview of Pentapeptide-31

Pentapeptide-31 is a pentapeptide, a synethsized chain protein created by linking five amino acid peptides (alanine, glutamic acid, glycine, leucine and serine.)

Function of Pentapeptide-31 in human skin

Pentapeptide-31, as a conditioning agent in personal care products, has many advantages, such as good compatibility with skin, easy absorption, good anti-aging and skin conservation effects. The usages of pentapeptide-31 are as follows:

1. Pentapeptide-31 helps boost the Stemness Recovery Complex ( in vitro, ex vivo)

2. Pentapeptide-31 helps preserve cells under conditions of stress (in vitro, ex vivo, in vivo)

3. In vivo data from clinical studies demonstrate improved appearance in skin and self-rejuvenation

In conclusion, you can use it even as a prevention measure. Peptides are one of those ingredients that are good to add to your "stay younger for longer" skin care routine.


1. Sakamoto, K., Lochhead, R., Maibach, H., & Yamashita, Y. (Eds.). (2017). Cosmetic Science and Technology: Theoretical Principles and Applications. Elsevier.

2. Msika, P., & Baudouin, C. (2015). U.S. Patent Application No. 14/766,602.

3. Baudouin, C., Bredif, S., & Msika, P. (2018). U.S. Patent No. 9,952,201. Washington, DC: U.S. Patent and Trademark Office.

4. Montiel, A. V. F., Doménech, N. A., Puche, J. C., Van Den Nest, W., Serraïma, C. C., & GONZÁLEZ, R. D. (2016). U.S. Patent No. 9,458,194. Washington, DC: U.S. Patent and Trademark Office.

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