The source and function of tripeptide-1 kollaren


Introduction of Tripeptide-1  

The tripeptide-1 (glycyl-L-histadyl-L-lysine or GHK) is primarily known as carrier peptides. It mainly helps to stabilize and deliver copper. GHK was originallyisolated from human plasma in 1973 by Pickart and Thaler and its wound repair properties were observed in 1985 by Maquart et al. In 1999, Maquart concluded that GHK or its copper complex functioned as an activator of tissue remodeling. It is also a signal peptide that promotes extra-large collagen aggregates degradation in scars, regular collagen synthesis in normal skin, elastin, proteoglycans production, growth rate and migration of different cell types, and anti-inflammatory and antioxidant responses. Since 1997, copper tripeptie-1 has been referred to as one of the most effective skin regeneration ingredients. This skin repairing peptide can help refine superficial scar tissue, even the skin tone and benefits those with acne, age spots, broken capillaries and rosacea.

An overview of Tripeptide-1 kollaren

The expression "tripeptides consisting of the amino acids glycine, histidine and lysine" particularly means the tripeptides of sequence Gly-His-Lys, the amino acids of which may be in the D. L. or DL form, optionally conjugated to a carboxylic acid such as acetic acid, in the form of a complex with a metal, such as zinc or copper. Among the tripeptides consisting of the amino acids glycine, histidine and lysine, the tripeptide "Kollaren-CPP" is preferably used, and its INCI name is "tripeptide-1". Kollaren-CPP is a tripeptide of sequence Gly-His-Lys conjugated to acetic acid (acetate), in the form of a complex with zinc.

As we age, collagen, the protein that gives skinfirmness and elasticity, gets degraded. Can peptides offset this process? Several in vitro and in vivo studies have proved that tripeptide-1 kollaren stimulates the synthesis of collagen and glycosaminoglycans.


From these two perspectives, amino acids and peptides may be the focus of extensive research as a place for biomaterials and a potential untapped field. As one of the most effective skin regenerative ingredients, Tripeptide-1 kollaren can increase the firmness of the skin by activating the extracellular matrix proteins synthesis.


1. Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International journal of cosmetic science, 31 (5), 327-345.

2. Zhang, L., & Falla, T. J. (2009). Cosmeceuticals and peptides. Clinics in dermatology, 27 (5), 485-494.

3. Galderisi, A. (2013). U.S. Patent Application No. 13/524,031.

4. Msika, P. (2013). U.S. Patent No. 8,466,109. Washington, DC: U.S. Patent and Trademark Office.

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