Function of palmitoyl tripeptide-38 in skin



Palmitoyl Tripeptide-38, named MATRIXYL synthe'6 and Volulip, a cosmetic peptide or double-oxidized lipopeptide, consisted of three amino acids, is the product of reaction between the palmitic acid and tripeptide-38. It is white or light white power and its molecular structural formula is just as shown in Fig.1. This peptide is pro-collagen lipopeptide which rebuilds the skin from the inside where it is needed, soothing wrinkles and skin especially for the forehead, crow's feet, heads and necks. Now, Palmitoyl Tripeptide-38 has become a popular cosmetic material for anti-wrinkle and anti-aging in our life and is developed to target different aspects involved in skin aging.


Fig 1. The molecular structure of Palmitoyl Tripeptide-38

Mechanism of anti-wrinkle and anti-aging

Palmitoyl Tripeptide-38 has the similar effect with matrikine, and it is an amino acid chain which has demonstrated the capacity to increase the production of dermal and epidermal components such as collagen (including tape I, III, and IV), fibronectin, hyaluronic acid (capacity of retention the water) and laminin 5 (a role in construction of epithelial basement membranes, cell adhesion, growth and differentiation). Therefore the palmitoyl tripeptide-38 promotes regeneration of skin to make wrinkles and skin smooth and delays the appearance of signs of aging. Furthermore, it also can deeply replenish nutrients, dilute lines of lip and increase elasticity.

Efficacy and application

The Palmitoyl Tripeptide-38, as a cosmetic raw material, plays an important role in our life. And it has many positive effects, for example, it can be as an ingredient associated with the serum in the cosmetic formula to decrease the appearance of fine lines and wrinkles, especially in forehead, crow's feet, heads and necks. The anti-wrinkle effect of the Palmitoyl Tripeptide-38 was also demonstrated clinically, and In-vitro studies have shown that the Palmitoyl Tripeptide-38 can be as an ingredient added into serum formulation, which could exert several and synergistic beneficial anti-aging effects at epidermal and dermal level, and most importantly, it results in a reduction of wrinkles and a dermis-redensifying and a skin smoothing effect. It may attract more attention of researchers and expected to be applied in the cosmetic filed, such as skin care products, and anti-wrinkle, anti-aging products and skin repair products, because of its special property and positive effects.


1. Sanz M T, Campos C, Milani M, Foyaca M, Lamy A, Kurdian K, and Trullas C. Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro‐collagen lipopeptide, creatine, and urea on skin aging signs. Journal of Cosmetic Dermatology. 2016, 15(1): 24-30.

2. Trookman N S, Rizer R L, Ford R, Mehta R, and Gotz V. Clinical assessment of a combination lip treatment to restore moisturization and fullness. J Clin Aesthet Dermatol. 2009, 2(12): 44-48.

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