Inhibitors

Introduction GRK2i, a GRK2 inhibitory polypeptide, specifically inhibits Gβγ activation of GRK2. It corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist. Pharmacologic actionGβγ

Introduction BA 1 (DTyr-Gln-Trp-Ala-Val- Ala-His-Phe-Nle-NH2) is a potent BRS-3 agonist (IC50 = 2.52 nM) and a NMBR and GRPR agonist (IC50 values are 0.26 and 1.55 nM respectively). It can stimulate N

Introduction  PR 39, a porcine 39-aa peptide antibiotic, was originally isolated from the upper part of the small intestine of the pig. PR 39 is compsed of 49% proline and 24% arginine, and 19 of whic

Introduction C 21 is a kind of selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM). And it exhibits five-fold selectivity for PRMT1 over protein arginine methyltransferase

Introduction Compstatin is a 13-residue cyclic peptide (Ile1-Cys2-Val3-Val4-Gln5-Asp6-Trp7-Gly8-His9-His10-Arg11-Cys12-Thr13-NH2) discovered by phage-display random peptide libraty with C3b. C3b is an

Introduction Conantokin-T (Gly-Glu-Gla-Gla-Tyr-Gln-Lys-Met-Leu-Gla-Asn-Leu-Arg-Gla-Ala-Glu-Val-Lys-Asn-Ala-NH2), a 21-amino acid peptide which induces sleep-like symptoms in young mice is purified fro

Introduction (d(CH2)51,Tyr(Me)2,Arg8)-vasopressin, a kind of vasopressin, is a prohormone in neurons in the hypothalamus. Vasopressin is synthesized by hormone and released into the circulation due to

Introduction 10Panx is a panx 1 mimetic inhibitor that easily and reversibly inhibits panx1 currents. In cells that are difficult to efficiently and continuously introduce siRNA, 10Panx allows researc

Introduction JIP1, a member of the JIPs family, was first discovered to promote JNK activation by combining multiple components of the JNK signaling pathway. JIP1 also has a JNK-binding domain (JBD) a

Introduction Appropriate perfusion preservation solution is of great significance for reducing or slowing down various damages during organ preservation, prolonging organ preservation time and improvi

Introduction Mambalgin 1, a toxin isolated from black mamba venom, is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger toxins. It is an effective, ra

Introduction NFAT, the nuclear factor of activated T cells, is a family of transcription factors that play an important role in inducing gene transcription in immune response. NFAT was firstly found i

Introduction P11 (HSDVHK) is a novel peptide ligand containing a PDZ-binding motif (Ser-Asp-Val) with high affinity to integrin αvβ3. It was identified from a hexapeptide library (PS-SPCL) using a pro

Introduction Gap 19 is a nonapeptide derived from the cytoplasmic loop (CL) of Connexin-43 (Cx43). Cx43 is a predominant cardiac connexin, and forms gap junctions (GJs) that facilitate electrical cell

Introduction GR 64349 is a selective and potent NK2 agonist (EC50 = 3.7 nM in rat colon) with activity comparable to that of neurokinin A (NKA). Besides, it displays > 1000- and > 300-fold selectivity

Introduction Huwentoxin IV, a 35-amino-acid-residue polypeptide from Chinese tarantula Ornithoctonus huwena venom, is a kind of selective NaV1.7 channel blocker. It preferentially inhibits neuronal Na

Introduction APC 366 [N-(1-hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide], is a novel selective inhibitor of mast cell tryptase. It is a small molecule, first-generation peptidic inhibitor that has bee

Introduction Jingzhaotoxin-III (β-TRTX-Cj1α) is a kind of sodium channel gating modifier which is from the tarantula Chilobrachys jingzhao. It can selectively inhibit the activation of cardiac sodium

Introduction GR 94800, is a linear heptapeptide with the structure of PhCO-Ala-Ala-D-Trp-Phe-D-Pro-Nle Amide, which is a highly potent and selective NK2 receptor antagonist. Incorporation of D-Pro9 in

Introduction Catestain, a 21 amino acid fragment of chromogranin A (CgA), is divided into human CgA352-372 and bovine CgA344-364. It is a cationic and hydrophobic peptide formed endogenously by proteo