Substance P and Analogs

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CAT# Product Name M.W Molecular Formula Inquiry
R0901 α-Bungarotoxin 7984.14 C338H529N97O105S11 Inquiry
R0903 RLLFT-NH2 647.82 C31H53N9O6 Inquiry
R0905 Ac9-25 2183.35 C99H143N23O33 Inquiry
R0906 Alpha-Conotoxin PIA 1981.3 C79H125N27O25S4 Inquiry
R0909 CH 275 1485.8 C74H96N14O15S2 Inquiry
R09100 Spexin-2 (53-70), human/mouse/rat 2159.5 Inquiry
R0913 Caffeic acid-pYEEIE 923.82 C39H50N5O19P Inquiry
R0914 Xenin 8 1046.28 C51H79N15O9 Inquiry
R0916 [D-Trp7,9,10]-Substance P 1588.89 C79H105N21O13S Inquiry
R0917 N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide 571.61 C26H42N3O9P Inquiry
R0923 [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide 4207.67 C183H281N57O54S2 Inquiry
R0925 Kisspeptin 10 (dog) 1330.51 C65H87N17O14 Inquiry
R0926 RFRP 3 (human) 969.15 C45H72N14O10 Inquiry
R0930 Galanin (2-29) (rat) 3107.42 C139H207N42O40 Inquiry
R0931 Nocistatin (human) 3561.93 C149H238N42O53S3 Inquiry
R0934 [Leu31,Pro34]-Neuropeptide Y (porcine) 4223 C190H286N54O56 Inquiry
R0940 Neuropeptide SF (mouse, rat) 888.03 C40H65N13O10 Inquiry
R0943 Apelin-17 (human, bovine) 2138.56 C96H156N34O20S Inquiry
R0944 A-71623 840.97 C44H56N8O9 Inquiry
R0947 Pseudo RACK1 3198.81 C144H225N43O34S3 Inquiry

Substance P, also known as neurokinin 1, belongs to the tachykinin neuropeptide family and is a neuropeptide that functions as a neurotransmitter and a neuromodulator. It is an 11-residue neuropeptide with the sequence Arg-Pro-Lys-Pro-Gln-Glin-Phe-Gly-Leu-Met-NH2). It is abundant in the areas of the brain responsible for regulating emotion (amygdala, periaqueductal gray matter, hypothalamus, etc.). At the same time, it is highly expressed in the cell body and nerve fibers of primary sensory neurons.

Mode of Action

Substance P is a neuropeptide widely distributed in fine nerve fibers. When the nerve is stimulated, substance P can be released at the central and peripheral terminals and play a physiological role in binding to the NK1 receptor. Substance P released at the terminal of the central end is related to the transmission of pain, and its C-terminal is involved in the transmission of pain, while the N-terminal can be reversed by naloxone. Substance P can participate in pain transmission directly or indirectly by promoting the release of glutamic acid, and its analgesic use is caused by promoting the release of encephalin. Reverse electrical stimulation of sensory nerve or axon reflex and dorsal root reflex from fine afferent fibers can slightly release substance P from the peripheral end, resulting in vasodilation and increased permeability in the dominant area of the nerve. Neurogenic inflammatory reactions such as plasma protein extravasation.

Function

The main function of substance P is to transmit pain information-peripheral nociceptive sensation is transmitted to the spinal dorsal horn or brain stem through C-type afferent fibers, releasing substance P and glutamic acid, activating secondary nociceptive neurons. Transmit pain information to the pain center in the brain. In addition, substance P in the brain is involved in the regulation of feeling, movement and emotion, and is related to the pathogenesis of anxiety disorder, depression and schizophrenia.

Reference

  1. O’Dorisio, M. S. (2018). The role of substance P, somatostatin and vasoactive intestinal peptide in modulation of mucosal immunity. In The Neuroendocrine Immune Network (pp. 187-198). CRC Press.
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