HIV-TAT Family

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CAT# Product Name M.W Molecular Formula Inquiry
GR12001C Cys-TAT (48-60) 1985.3 Inquiry
GR1201 Biotin-TAT (47-57) 1786.2 Inquiry
GR1202 FITC-LC-TAT (47-57) 2061.4 Inquiry
GR1204 TAT (47-57) 1559.9 C64H118N32O14 Inquiry
GR1205 D-TAT (47-57) 1559.9 Inquiry
GR1206 TAT (48-57) 1396.7 Inquiry
GR1207 TAT- C (48-57) 1499.8 Inquiry
GR1208 TAT (47-57) GGG-Cys(Npys) 1987.3 Inquiry
GR1209 TAT (47-57), FAM-labeled 1918.2 Inquiry
GR1210 TAT (47-57), TAMRA-labeled 1972.4 Inquiry
GR1211 Cys(Npys)-TAT (47-57) 1816.1 Inquiry
GR1213 R9-TAT 1803.1 Inquiry
GR1214 Tat-Beclin-1 Inquiry
GR1215 Tat-Beclin-1, scrambled Inquiry
GR1216 TAT-GluR23A Fusion Peptide 2357.7 Inquiry
GR1217 Tat-GluR23Y 2634 Inquiry
GR1218 Tat-GluR23Y, scrambled 2634 Inquiry
GR1219 TAT-HA2 Fusion Peptide 3433 Inquiry
GR1220 Tat-NR2Bct 2518.9 Inquiry
GR1221 TAT-NSF222 Fusion Peptide 4239.9 Inquiry

What's cell-penetrating peptides?

The selective permeability of cell membranes plays a very important role in maintaining the stability of the intracellular environment, but this property of cell membranes restricts the entry of some biomolecules and drugs into cells, which is not conducive to the diagnosis of some intracellular diseases and the application of drug-targeted therapy. How to get some biomolecules and drugs with diagnostic and therapeutic potential through the cell membrane into the cell has been a hot and difficult research issue in the medical community. Cell-penetrating peptides are short peptides that can carry peptides, proteins, nucleic acids, nanoparticles, viral particles and drugs across cell membranes and into cells, leading to the internalization of intact carriers, providing a powerful vehicle for biomolecules and drugs to enter cells. Currently, cell-penetrating peptides have shown potential diagnostic and therapeutic applications as carriers of biomolecules and drug internalisation in fluorescence imaging, tumour therapy, anti-inflammatory therapy and drug-targeted therapy. HIV-TAT Family Nuclear is the first cell-penetrating peptide to be identified.

What's HIV-TAT Family Nuclear?

HIV-TAT is the trans-activator of transcription (Tat) protein of human immunodeficiency virus (HIV), which was discovered by Frankel in 1988 to enter cultured cells and promote viral gene expression. HIV-TAT can enter cells directly through the membrane in a non-energy and temperature-dependent manner. Veach et al. found that Tat proteins were internalised with the same efficiency at 4℃ and 37℃ and that the internalisation process was not blocked in ATP deleted cells.

Application of HIV-TAT Family Nuclear

Among the range of applications for HIV-TAT Family Nuclear, the most valuable is as a delivery vehicle to promote the effectiveness of drugs in the treatment of disease. Its ability to introduce drugs and other therapeutic molecules into cells gives the membrane penetrating peptide great therapeutic potential. For example, TAT-linked p53 protein (RI-TAT-p53C) and R11-linked p53 protein and haemagglutinin HA-2 (d11R-p53C-riHA2) were effective in promoting tumour cell apoptosis and prolonging the life span of mice after intraperitoneal injection into a lymphoma mouse model. p53 is a tumour suppressor and mutations in p53 are found in 50% of tumours. The TAT-linked P15 protein has also been shown to have tumour suppressive effects in several tumour cell models and in vivo experiments.

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