ACTH and Related Peptide Sequences

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CAT# Product Name M.W Molecular Formula Inquiry
A03001 (Des-His6)-ACTH (1-24) (human, bovine, rat) 2796.34 C130H203N37O30S Inquiry
A03002 (Des-Ser3)-ACTH (1-24) (human, bovine, rat) 2846.40 C133H205N39O29S Inquiry
A03006 (Tyr15)-ACTH (7-15) 1109.3 C55H76N14O11 Inquiry
A03007 [Glu10]-ACTH (1-17) 2165.5 Inquiry
A03010 Acetyl-ACTH (1-14) 1722.95 C79H111N21O21S Inquiry
A03011 Acetyl-ACTH (2-24) (human, bovine, rat) 2888.44 C135H207N39O30S Inquiry
A03012 Acetyl-ACTH (3-24) (human, bovine, rat) 2725.26 C126H198N38O28S Inquiry
A03013 Acetyl-ACTH (4-24) (human, bovine, rat) 2638.19 C123H193N37O26S Inquiry
A03014 Acetyl-ACTH (7-24) (human, bovine, rat) 2240.73 C107H170N32O21 Inquiry
A03015 ACTH (1-10) 1299.4 Inquiry
A03019 ACTH (1-16), human 1937.3 C89H133N25O22S1 Inquiry
A03021 ACTH (12-39), rat 3173.9 C145H227N39O41 Inquiry
A03022 ACTH (1-24), human 2933.5 Inquiry
A03023 ACTH (1-39) (mouse, rat) 4582.23 C210H315N57O57S Inquiry
A03024 ACTH (1-39), guinea pig 4529.2 C206H308N56O58S Inquiry
A03025 ACTH (1-39), human 4541.1 Inquiry
A03026 ACTH (1-4) 486.5 Inquiry
A03027 ACTH (18-39), human (CLIP) 2465.7 Inquiry
A03029 ACTH (2-24) (human, bovine, rat) 2846.40 C133H205N39O29S Inquiry
A03030 ACTH (3-24) (human, bovine, rat) 2683.23 C124H196N38O27S Inquiry


Adrenocorticotropic hormone (ACTH) is a linear peptide with α-melanocyte stimulating hormone (α-MSH) and corticosteroid-like mid-leaf peptides derived from pro-opiomellin precursor. ACTH contains 39 amino acids, of which 1-24 are essential amino acids that constitute biological activity, and 25-39 are protective amino acids. The 20 to 24 residues of ACTH have a negative regulation of its bioavailability and are important for the action of corticosteroid-like peptides, while corticosteroid-like peptides can inhibit N-methyl-D-aspartate. ACTH is mainly produced from the anterior pituitary, and ACTH in the middle pituitary is mainly present as an intermediate of biosynthesis. In human body, ACTH is widely distributed in many tissues such as immune cells. The distribution of ACTH in the central nervous system is also extensive.

Mechanism of action

ACTH is an important member of hypothalamic-pituitary-adrenal axis (HPAA) by increasing 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol side chain oxidase activity, promoting the synthesis of corticosteroids. ACTH is also responsible for the regulation of corticosteroids and corticotropin-releasing hormone (CRH) to maintain normal HPA axis activity and promote adrenal gland development. ACTH has an effect on energy production and glucose metabolism by enhancing the activity of other enzymes. ACTH-related receptors are widely distributed in the central system and immune cells, suggesting that ACTH has a regulatory effect on both the immune system and the neuroendocrine system. In the nervous system, ACTH can not only increase brain gene transcription, but also promote synapse formation and regeneration at neuromuscular junctions.

Application of ACTH and Related Peptide Sequence

ACTH is a regulator of the neuroendocrine system that directly or indirectly affects the development of the nervous system, especially the brain. By binding to different receptors, ACTH activates known or unknown signaling pathways, promoting brain development during embryos. ACTH also repairs the damage caused by stress, hypoxia and ischemia. An in-depth understanding of the effects of ACTH will help to understand the role of ACTH in many neuropsychiatric disorders (such as infantile spasms), which has a significant effect on the treatment of related diseases and the development of other non-hormonal drugs.


  1. Arnason, B. G., Regina, B., Anna, C., Lisak, R. P. & Mone, Z. Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis. Multiple Sclerosis 19, 130-136 (2013).
  2. Iwayama, H. et al. Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review. Bmc Endocrine Disorders 18, 19 (2018).
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