Potent melanocortin receptor agonist and endogenous adrenocorticotropic hormone (ACTH) fragment
CAT No: R1830
CAS No:4037-01-8
Synonyms/Alias:ACTH (4-10);4037-01-8;Met-glu-his-phe-arg-trp-gly;4-10-Semax;corticotropin (4-10);Msh-acth (4-10);ACTH 4-10;H-Met-Glu-His-Phe-Arg-Trp-Gly-OH;N-(N-(N(2)-(N-(N-(N-L-Methionyl-L-alpha-glutamyl)-L-histidyl)-L-phenylalanyl)-L-arginyl)-L-tryptophyl)glycine;UNII-J48AU3I790;J48AU3I790;(4S)-4-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;GLYCINE, L-METHIONYL-L-.ALPHA.-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-ARGINYL-L-TRYPTOPHYL-;corticotropin 4-10;ACTH-MSH (4-10);human ACTH (4-10);porcine ACTH (4-10);ACTH - msh (4-10);4-10-Corticotropin;ACTH4-10;CHEMBL2028951;DTXSID001031210;HY-P1478;(5S,8S,11S,14S,17S)-14-((1H-Imidazol-4-yl)methyl)-5-((1H-indol-3-yl)methyl)-17-((S)-2-amino-4-(methylthio)butanamido)-11-benzyl-8-(3-guanidinopropyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid;MS-31803;PD100148;CS-0044415;G12436;Q27281179;GLYCINE, L-METHIONYL-L-ALPHA-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-ARGINYL-L-TRYPTOPHYL-;
Chemical Name:Adrenocorticotropic Hormone (ACTH) (4-10), human
ACTH (4-10), also known as Adrenocorticotropic Hormone fragment 4-10, is a synthetic peptide corresponding to a specific heptapeptide sequence derived from the N-terminal region of the full-length ACTH polypeptide. As a bioactive peptide, it retains certain functional motifs of the parent hormone while lacking the complete structure necessary for full receptor activation, making it a valuable tool in neuroendocrinology and peptide signaling research. The distinct sequence of ACTH (4-10) has been widely studied for its role in modulating central nervous system activities, peptide-receptor interactions, and as a model for investigating structure-activity relationships within melanocortin peptides.
Neuroscience research: ACTH (4-10) is frequently utilized in studies exploring peptide-mediated signaling within the central nervous system. Its sequence encompasses motifs that interact with neural receptors, allowing researchers to dissect the contributions of specific peptide fragments to neuropeptide action. Investigations often focus on synaptic transmission, neuroplasticity, and the modulation of neurotransmitter release, providing insight into the molecular underpinnings of peptide-regulated neurological processes.
Behavioral studies: As a truncated fragment of ACTH, this peptide has been employed in behavioral pharmacology to examine its effects on learning, memory, and stress responses in animal models. By isolating the activity of the 4-10 sequence, researchers can distinguish the cognitive and behavioral influences attributable to this region from those of the full-length hormone. Such studies contribute to a nuanced understanding of how specific peptide domains influence complex behavioral phenotypes.
Peptide-receptor interaction analysis: The defined structure of ACTH (4-10) makes it an ideal candidate for probing the binding characteristics and activation profiles of melanocortin and other G-protein-coupled receptors. By employing this fragment in binding assays and functional studies, scientists can elucidate the minimal structural requirements for receptor engagement, facilitating the development of selective ligands and antagonists for research purposes.
Structure-activity relationship investigations: The heptapeptide serves as a model compound for examining how sequence truncation and modification impact biological function. Through systematic substitution or modification of amino acid residues within ACTH (4-10), researchers can map critical determinants of peptide activity, stability, and receptor specificity. These studies inform the rational design of novel peptide analogs with tailored biological properties for use in basic and applied research.
Peptide synthesis and analytical method development: ACTH (4-10) is also valuable as a reference standard and synthetic intermediate in the development of peptide synthesis protocols and analytical techniques. Its well-characterized sequence and manageable size make it suitable for optimizing solid-phase peptide synthesis strategies, validating chromatographic methods, and calibrating mass spectrometry instrumentation. This facilitates the reliable production and analysis of research-grade peptides across various laboratory settings.
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