CEF1, Influenza Matrix Protein M1 (58-66) is an epitope derived from the matrix protein of the influenza A virus.
CAT No: R1275
CAS No:141368-69-6
Synonyms/Alias:141368-69-6;(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S,3S)-2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoic acid;CEF1, Influenza Matrix Protein M1 (58-66);Matrix protein 1 (58-66);H-Gly-Ile-Leu-Gly-Phe-Val-Phe-Thr-Leu-OH; H-GILGFVFTL-OH;CHEMBL1869460;HY-P0137;NCGC00167248-01;FM110246;DB-230502;CS-0019779;Matrix protein m1(58-66)(influenza a virus);Matrix Protein M1 (58-66) (Influenza A virus) trifluoroacetate salt;Glycyl-l-isoleucyl-l-leucylglycyl-l-phenylalanyl-l-valyl-l-phenylalanyl-l-threonyl-l-leucine;944284-22-4;
CEF1, Influenza Matrix Protein M1 58-66 is a synthetic peptide fragment corresponding to amino acids 58 through 66 of the Influenza A virus matrix protein M1. As a well-characterized epitope, it is widely recognized for its ability to stimulate cytotoxic T lymphocyte (CTL) responses, making it a valuable tool in immunological research. The peptide's defined sequence and immunodominant properties have established its significance in studies focused on viral immunity, T-cell specificity, and antigen processing. Its use spans fundamental investigations into host-pathogen interactions and the mechanistic evaluation of cellular immune responses to influenza virus infection.
Immunological Assays: The M1 58-66 peptide serves as a gold standard antigen for evaluating CTL activity in various immunological assays, including ELISPOT, intracellular cytokine staining, and chromium release assays. By presenting this epitope to T cells in vitro, researchers can reliably monitor the magnitude and specificity of CD8+ T-cell responses, enabling detailed characterization of immune reactivity against influenza virus. Its consistent performance supports the development of robust, reproducible protocols for assessing T-cell function in both basic and translational research settings.
Epitope Mapping: Utilization of the peptide in epitope mapping studies allows for precise identification of T-cell determinants within the influenza matrix protein. By facilitating the dissection of antigenic regions recognized by CTLs, the fragment aids in pinpointing immunodominant sites and understanding the molecular basis of immune recognition. These insights are critical for elucidating the mechanisms underlying T-cell mediated protection and for informing the rational design of next-generation vaccines targeting conserved viral epitopes.
Vaccine Development Research: The M1 58-66 peptide is frequently employed in preclinical research to evaluate candidate vaccine formulations and adjuvant systems. Its inclusion in peptide pools or as a standalone immunogen enables the assessment of vaccine-induced cellular immunity, particularly the induction of memory and effector T-cell populations. By serving as a benchmark antigen, it helps determine the efficacy of novel vaccine strategies aimed at eliciting broad and durable antiviral responses.
HLA Restriction Analysis: As a well-characterized HLA-A*0201-restricted epitope, the peptide is instrumental in studies exploring the relationship between major histocompatibility complex (MHC) presentation and T-cell activation. Researchers use it to examine HLA-restricted antigen processing, cross-presentation, and the influence of peptide-MHC binding affinity on immune recognition. These investigations contribute to a deeper understanding of host genetic factors that shape the quality and magnitude of antiviral immunity.
Quality Control and Standardization: In addition to its experimental applications, the peptide is frequently utilized as a positive control in immunological assay development and validation. Its robust and predictable immunogenicity ensures the reliability of assay performance, providing a critical reference point for quality control and standardization across laboratories and experimental platforms. This role is essential for harmonizing data interpretation and ensuring reproducibility in complex immunomonitoring studies.
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