Desmopressin acetate trihydrate is the trihydrate of the acetic acid salt of desmopressin. An antidiuretic, it increases urine concentration and decreases urine production, and is used to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function. It contains a desmopressin acetate (anhydrous).
CAT No: R1964
CAS No:62357-86-2
Synonyms/Alias:deamino-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-D-arginyl-glycinamide (1->6)-disulfide; acetic acid; hydrate
Chemical Name:acetic acid;(2S)-N-[(2R)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;trihydrate
Desmopressin Acetate Trihydrate is a synthetic peptide analogue structurally related to the natural antidiuretic hormone vasopressin. Characterized by its modified amino acid sequence and enhanced stability, this compound exhibits a high degree of selectivity for vasopressin V2 receptors. Its unique molecular features, including resistance to enzymatic degradation and increased bioavailability, have established it as a valuable tool in diverse areas of biochemical research. The compound's trihydrate form offers additional solubility and handling advantages, making it particularly suitable for laboratory applications that require precise control over peptide concentration and activity.
Receptor Binding Studies: As a highly selective V2 receptor agonist, desmopressin analogues are widely used to investigate the molecular mechanisms underlying vasopressin receptor signaling. Researchers employ this peptide to delineate the pharmacological profiles of V2 receptors in various cell systems, enabling detailed characterization of receptor-ligand interactions, downstream signaling cascades, and receptor desensitization or internalization processes. These studies contribute critical insights into receptor structure-function relationships and facilitate the development of novel receptor modulators.
Signal Transduction Research: The compound's ability to specifically activate the cAMP-dependent pathway via V2 receptor stimulation makes it a powerful probe for dissecting intracellular signaling networks. Experimental models utilizing desmopressin derivatives allow scientists to monitor the activation of adenylyl cyclase, protein kinase A, and subsequent transcriptional responses in renal and extrarenal tissues. Such investigations are instrumental in mapping the physiological and pathophysiological roles of vasopressin-mediated signaling, as well as in evaluating the selectivity and efficacy of new pharmacological agents targeting these pathways.
Water Transport and Renal Physiology Models: Due to its functional mimicry of endogenous antidiuretic hormone, this synthetic peptide is extensively applied in studies exploring water reabsorption mechanisms in the kidney. It serves as a reference compound in functional assays assessing aquaporin-2 trafficking, collecting duct responsiveness, and osmoregulatory processes. These applications are essential for elucidating the molecular basis of water balance disorders and for screening compounds that modulate renal water transport.
Peptide Stability and Degradation Assays: The enhanced metabolic stability of desmopressin analogues provides a robust model for evaluating peptide degradation pathways and protease activity in vitro. By comparing the resistance of this compound to enzymatic cleavage against other peptide substrates, researchers can quantify the efficiency of different proteolytic systems and assess the impact of sequence modifications on peptide half-life. Such assays are valuable both for basic enzymology and for the rational design of next-generation peptide therapeutics with improved stability profiles.
Peptide Synthesis and Analytical Method Development: Owing to its well-defined structure and physicochemical properties, desmopressin derivatives are frequently utilized as reference standards in peptide synthesis validation and analytical method optimization. Laboratories leverage this compound in the calibration of chromatographic systems, mass spectrometric analyses, and peptide purification protocols. Its consistent performance supports the development of reliable quality control methods, ensuring accuracy and reproducibility in peptide research and manufacturing workflows.
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