Triptorelin

Triptorelin is a gonadotropin releasing hormone (GnRH) agonist that is a potent inhibitor of the synthesis of testosterone (in men) and estrogen (in women) and is used to treat advanced prostate cancer.

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CAT No: R1945

CAS No: 57773-63-4

Synonyms/Alias: TRIPTORELIN;57773-63-4;Triptoreline;Triptorelina;Arvekap;Triptorelinum;Triptodur;(D-Trp6)-GnRH;Triptorelin pamoate;Decapeptyl;tryptorelin;Diferelin;Trelstar;D-Tryptophan-LH-RH;Diphereline;pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2;UNII-9081Y98W2V;CHEBI:63633;CL 118532;CL-118532;CL 118,532;BIM 21003;Wy 42422;[D-Trp6]-LH-RH;Triptoreline [INN-French];Triptorelinum [INN-Latin];Triptorelina [INN-Spanish];AY-25650;DTXSID2048375;Pamorelin;Salvacyl;Trelstar depot;9081Y98W2V;5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide;Trelstar LA;(D-Trp6)-LH-RH;Triptoreline (INN-French);Triptorelinum (INN-Latin);Triptorelina (INN-Spanish);6-D-tryptophan-LH-RH;D-Trp-6-LH-RH;LHRH, Tryptophyl(6)-;Wy 42462;GnRH, Trp(6)-;LHRH, Trp(6)-;Detryptoreline;AY 25650;Trellasar;Moapar;Triptorelin [USAN:INN:BAN];Decapeptyl SR;Pamorelin LA;Triptorelin (swine);Wy-42462;D-Trp6-LHRH;Debio-8206;Triptorelin (USAN/INN);TRIPTORELIN (MART.);GTPL1177;SCHEMBL5079698;CHEMBL1201334;DTXCID8028349;SCHEMBL22289009;L02AE04;VXKHXGOKWPXYNA-PGBVPBMZSA-N;HMS2090C17;EX-A3857;BIM-21003;AKOS030213249;CS-5745;DB06825;NCGC00167301-01;NCGC00167301-02;AS-71149;BN-52014;DA-48936;HY-12551;CL-118,532;C75704;D06247;[D-Trp6]-LH-RH, >=97% (HPLC), powder;AB01275488-01;6-D-Tryptophanluteinizing Hormone-releasing Factor;A936467;EN300-18527985;pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-GlyNH2;Q1992452;BRD-K62685538-001-01-7;(S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-5-yl)methyl)-6,15-bis((1H-indol-3-yl)methyl)-21-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide;Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-;

Chemical Name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

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M.F/FormulaC64H82N18O13
M.W/Mr.1311.4
SequenceOne Letter Code:XHWSYWLRPG
Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
AppearanceSolid powder
Biological ActivityTriptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor. It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells.
TargetGonadotropin-releasing hormone (GnRH)
Long-term Storage ConditionsSoluble in DMSO
InChIInChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1
InChI KeyVXKHXGOKWPXYNA-PGBVPBMZSA-N
Canonical SMILESCC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
Isomeric SMILESCC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
References

A total of 22 months' worth of data were analyzed (or 1 041 638 total items, monthly average 47 347 items). Goserelin; leuprorelin, and triptorelin are the medicines most used by total quantity in the study period. Simple descriptive statistics show that mean values have declined during the pandemic. The Interrupted Time Series (ARIMA Modeling) shows declining trends.

Ravina Barrett, Robert Barrett, Kalyan Dhar, Gonadorelins adherence in prostate cancer: A time-series analysis of England’s national prescriptions during the COVID-19 pandemic (from Jan 2019 to Oct 2020)

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