Secretin (swine) presents immense potential in ameliorating gastrointestinal afflictions, including pancreatic insufficiency and exocrine pancreatic dysfunction. By imparting vigorous stimulation to exocrine pancreas, it facilitates remarkable pancreatic enzyme and bicarbonate secretion, thus conspicuously augmenting digestive prowess.
CAT No: R1985
CAS No:17034-35-4
Chemical Name:(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[2-[[(2S)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid
Secretin (swine) is a peptide hormone belonging to the secretin family, characterized by its sequence homology and functional similarity to endogenous secretin found in mammals. As a regulatory peptide, it plays a fundamental role in modulating pancreatic secretion and gastrointestinal physiology, making it a significant subject in biochemical and physiological research. Derived from porcine sources, this peptide is widely utilized in studies aiming to dissect the mechanisms of hormone-receptor interactions, signal transduction pathways, and the broader regulatory networks governing digestive processes. Its well-defined structure and conserved biological activity render it a valuable tool for elucidating peptide hormone function and advancing peptide-based research methodologies.
Receptor binding studies: Secretin (swine) serves as a key ligand in investigations of G protein-coupled receptor (GPCR) biology, specifically targeting the secretin receptor (SCTR). Researchers employ it to characterize receptor affinity, specificity, and downstream signaling events, enabling a deeper understanding of ligand-receptor dynamics in both physiological and pharmacological contexts. Such studies are essential for mapping the structural determinants of peptide recognition and for developing new modulators of secretin receptor activity.
Signal transduction research: The peptide is frequently utilized to probe intracellular signaling cascades initiated by receptor activation. Upon binding to its cognate receptor, secretin triggers cyclic AMP (cAMP) production and activates protein kinase A (PKA) pathways within target cells. By applying this peptide in controlled experimental systems, investigators can dissect the molecular events that underlie second messenger generation, kinase activation, and the regulation of gene expression in response to peptide hormones. These insights contribute to the broader field of cell signaling and endocrine regulation.
Gastrointestinal physiology modeling: Secretin (swine) is instrumental in experimental models designed to analyze pancreatic exocrine secretion and bicarbonate production. By administering the peptide to isolated tissue preparations or organ systems, scientists can quantify its effects on fluid and electrolyte transport, enzyme release, and overall digestive function. Such applications are critical for clarifying the physiological roles of regulatory peptides in the gastrointestinal tract and for developing in vitro models that recapitulate in vivo hormone responses.
Peptide structure-function analysis: The defined amino acid sequence and conserved biological activity of this peptide make it an excellent candidate for structure-activity relationship (SAR) studies. Researchers synthesize analogs or introduce modifications to the native sequence to investigate how specific residues contribute to receptor binding, biological potency, and metabolic stability. These experiments provide valuable information for peptide engineering, optimization of bioactive analogs, and the design of novel research tools targeting secretin-related pathways.
Assay development and validation: Secretin (swine) is widely employed as a standard or positive control in the development of biochemical assays for hormone detection, receptor activity measurement, and signal transduction monitoring. Its consistent activity and well-characterized properties support the establishment of robust, reproducible assay systems for both basic research and high-throughput screening applications. By enabling accurate quantification and functional assessment, the peptide facilitates advancements in peptide research, assay technology, and the study of endocrine signaling networks.
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