C3a and C3d Peptides

* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

Online Inquiry

CAT# Product Name M.W Molecular Formula Inquiry
C01001 (Tyr69,Ala71.72,Lys74)-C3a (69-77) 976.19 C45H77N13O11 Inquiry
C01004 C3a (72-77) (human) 665.79 C29H51N11O7 Inquiry
C01005 C3d Peptide P16 1947.14 C86H131N25O27 Inquiry
C01006 [Trp63, 64]-C3a (63-77) 1820.2 Inquiry
C01008 C3f fragment, Human c3 (1286-1297) 1449.6 Inquiry
C01009 C3f, Human c3 (1282-1298) 2021.3 Inquiry
C01010 Complement anaphylatoxin C5a (37-53), human 1889.3 Inquiry


The third component of complement (C3) is the core of the complement system, which was discovered in 1912 when Ritg treated serum with snake venom. C3 convertase acts on amino acids 77-78 of the complement C3 molecule and cleaves it into C3a and C3b. C3a peptide is an allergen that triggers inflammatory responses which mediated by complement. C3a peptide is an anaphylatoxin molecule produced by the activation of the replenishment system. In mammals, C3a is thought to be an endogenous signal that induces an inflammatory response and is also an inducer that activates several key innate immune processes. C3b peptide is an opsonin that enhances the phagocytosis ability of phagocytic cells. C3b peptide is an important opiner (op2 sonin) that binds bacteria or other particles quickly and binds to receptors on the surface of neutrophils, mononuclear or macrophages, promoting the phagocytosis of pathogens. Both C3a and C3b play important roles in both the classical and alternative pathways of complement activation.

Mechanism of action

C3 molecules, including C3a and C3b, have numerous binding sites with other molecules, which are the molecular basis for the biological activity of complement. C3aR is receptor of C3a peptide. In mammals, C3aR is the only seven-transmembrane member of the rhodopsin family. C3aR is mainly found in lymphocytes and granulocytes in the blood. C3b binds to complement type I receptor (CR1, CD35) abundantly present on red blood cells, neutrophils, monocytes and macrophages via the CR1 binding site. This mainly mediates the clearance of antigen-antibody complexes and promotes phagocytosis of phagocytic cells.

Application of C3a and C3d Peptides

It has been reported that the determination of serum complement C3a and C3b levels can help determine the potential activity of systemic lupus erythematosus and guide the rational use of corticosteroids. Plasma complement C3 and C3/C3b values in patients with chronic hepatitis B are important parameters for judging the severity of hepatitis. C3a and C3b peptides are associated with a variety of effector cells, play an immunomodulatory role, and are widely used in clinical testing and vaccine preparation. They are important for the diagnosis and prevention of diseases.


  1. Lambris, J.D., Reid, K.B., Volanakis, J.E. (1999) The evolution ,structure ,biology and pathophysiology of complement. Immunol Today, 20 (5): 207-211.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Customer Support & Price Inquiry

Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!

  PKC (19-36), a synthetic peptide of the pseudosubstrate domain of the kinase, is a selective inhibitor of prote ...

 Tetracosactide (also known as Tetracosactide) is a synthetic peptide that is identical to the 24-amino acid segm ...

 In 1979, GOLDSTEIN et al. extracted an opioid-active 17 peptide from the pituitary of pigs and named it dynorphi ...

Octreotide, a long-acting structural derivative of somatostatins, is a synthetic peptide analog of somatostatin with the same ...

 Conantokin-T (Gly-Glu-Gla-Gla-Tyr-Gln-Lys-Met-Leu-Gla-Asn-Leu-Arg-Gla-Ala-Glu-Val-Lys-Asn-Ala-NH2), a 21-amino a ...

Quick Inquiry
Contact Us



Tel: |




Copyright © 2024 Creative Peptides. All rights reserved.