Thyrotropin-Releasing Hormone (TRH), Analogs and Related Peptides

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CAT# Product Name M.W Molecular Formula Inquiry
T08002 (Glu2)-TRH C15H22N4O6 Inquiry
T08003 pE-E-P--NH2 C15H23N4O6 Inquiry
T08004 Thyrotropin-Releasing Hormone (TRH) C16H22N6O4 Inquiry
T08005 TRH, Free Acid C16H21N5O5 Inquiry
T08006 (Phe2)-TRH C19H24N4O4 Inquiry
T08007 [Glu1] TRH C16H23N6O5 Inquiry
T08008 Pyr--His-Pro-Gly--NH2 C18H25N7O5 Inquiry
T08009 pE-H-P-G C18H24N6O6 Inquiry
T08010 TRH-Gly C18H24N6O6 Inquiry
T08011 TRH--AMC C26H28N6O6 Inquiry
T08012 pE-H-P-G-K C24H36N8O7 Inquiry
T08015 [Ala26] - Melan - A/MART - 1 (26 - 35) 885.1 Inquiry
T08016 Thrombin Receptor Peptide Ligand, Thrombin Receptor Antagonist Inquiry
T08017 [Leu27] - Melan - A, MART 1 (26 - 35) 985.8 Inquiry
T08018 Thyrotropin Releasing Hormone Precursor Peptide, TRH Precursor Peptide Inquiry
T08019 CDPKS, Syntide analog Inquiry
T08020 GRPRTSSFAEG Inquiry
T08021 Prepro TRH (160-169) C54H75N11O18S1 Inquiry
T08022 TRH-SH Pro C48H83N21O12S2 Inquiry
T08025 Crabrolin Inquiry

Introduction

Thyrotropin-releasing hormone (TRH), also known as thyroid liberating hormone, is the first recognized hypothalamic release factor, but the peculiar N-(pyroGlu) and C-terminal (amide) residues delayed solving its TRH structure. TRH has been shown to be a broad biological response. In addition to regulating the central role of the pituitary-thyroid axis by mimicking the release of thyroid stimulating hormone, TRH has a considerable influence on the activity of many neurobiological systems. The development of selective and metabolically stable TRH analogues is an interesting area due to the potential of TRH to treat several central nervous system diseases. By modifying three amino acid residues, TRH analogs were synthesized, which improved their stability, potency, and showed different pharmacological effects from the parent peptide. Peptides with the structure pGlu-X-ProNH2, where X can be any amino acid residue, are collectively called TRH-like peptides.

Mechanism of action

The pharmacological effects of TRH can be roughly divided into endocrine effects and central nervous system (CNS) stimulation. TRH plays a key role in the regulation of HPT axis feedback to maintain thyroid homeostasis. TRH is a neuromodulator of several different neurotransmitters, including the most prominent dopamine, serotonin, acetylcholine, and opioids, which regulate the effects of many drugs that affect these neurotransmitters and other neurotransmitters. TRH is also likely to act as a neurotransmitter through a specific receptor that is widely distributed in the central nervous system and is rapidly cleared by specific catabolic pathways. Pharmacological studies have shown that TRH and its analogs can inhibit seizures induced by rat igniting and PTZ or glutamate.

Application of TRH and its analogs

The potential therapeutic application of TRH is not its endocrine effect, but rather its extensive stimulatory effects in the central nervous system. TRH and its analogs can counteract the inhibitory effects of drugs such as pentobarbital on the central nervous system. TRH and some of its analogs have been evaluated for beneficial effects in various shock states, cerebrovascular diseases, and spinal cord injuries. Recent studies, including the role of TRH in regulating the "steady state" of the nervous system, have also provided new avenues for the discovery of potent selective central nervous system activity TRH analogs. Clinically, TRH is effective in the treatment of intractable epilepsy such as infantile spasm, Lennox-Gaston syndrome, myoclonic seizures, and other extensive refractory partial epilepsy.

References

  1. Monga, V., Meena, C. L., Kaur, N., & Jain, R. (2008). Chemistry and biology of thyrotropin-releasing hormone (TRH) and its analogs. Current medicinal chemistry, 15(26), 2718-2733.
  2. Fr?hlich, E., & Wahl, R. (2018). The forgotten effects of thyrotropin-releasing hormone: metabolic functions and medical applications. Frontiers in neuroendocrinology.
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