Creative Peptides has a fast and high-throughput parallel peptide synthesis platform. We are committed to providing high-quality random peptide library services according to customer needs. Our synthetic random peptide library provides a flexible choice from crude products to 98% purity.
The design of random peptide library is designed to replace selected amino acid residues simultaneously and randomly with 20 natural amino acids through shotgun approach. Our scientists can also design random libraries with specific physical and chemical properties to produce random peptide libraries with defined sizes and properties for target identification and drug discovery. Random peptide libraries excited by natural toxins or bioactive peptide have attracted much attention because of their great advantages as screening resources and physicochemical and pharmacological properties.
In order to prepare a random peptide library, random sequences are bound to specific positions in the scaffold (e.g., fibronectin, protein A, and Ankyrin, or Lipocalin). All of these proteins are soluble and thermostable, and the yield of recombinant expression is very high. Similar to minimized antibodies, initially selected proteins are usually further adjusted through engineering called "maturity" to improve their properties, such as affinity and specificity.
A random peptide library consists of a collection of peptides with randomly varied amino acid sequences. These libraries are created by replacing selected residues with 20 natural amino acids in a shotgun approach. This allows for high diversity in peptide sequences, making them ideal for applications such as target identification, drug discovery, and ligand optimization.
Random peptide libraries are widely used in peptide sequence optimization, drug discovery, target identification, and enhancing peptide activity. They are also used to predict antibody epitopes and discover alternative peptides with enhanced properties, offering a flexible resource for many applications in biochemistry and biotechnology.
Creative Peptides ensures high-quality synthesis of random peptide libraries with a purity range from 70% to over 90%. Each peptide product undergoes rigorous QC checks, including RP-HPLC, Mass Spectrometry (MS), and Certificate of Analysis (COA), guaranteeing the reliability and precision of the synthetic peptides.
Creative Peptides offers fast library synthesis with reliable delivery times of 2-3 weeks. We also provide customized peptide library designs based on specific customer needs, along with in-situ synthesis and chemical conjugation of peptides. No third-party outsourcing ensures full control over the process, ensuring consistent quality.
Yes, Creative Peptides can design random peptide libraries with specific physical and chemical properties tailored to your application. This customization includes designing libraries for target identification, ligand discovery, peptide activity enhancement, and even predicting antibody epitopes, depending on the project's requirements.
Peptides in the random library are synthesized using in-situ peptide synthesis and chemical conjugation. The final product is lyophilized into 96-well plates or individual vials, making it easy for customers to use in their research. A detailed QC report is provided with every batch, ensuring the quality and integrity of the peptides.
The peptides in a random peptide library from Creative Peptides typically have a purity ranging from 70% to over 90%, depending on the requirements of the specific project. Higher purity can be achieved upon request, and QC measures ensure that each peptide meets the specified purity standards.
Creative Peptides offers a range of random peptide libraries, including libraries for target identification, peptide activity enhancement, and ligand discovery. These libraries can be designed based on specific scaffold proteins, such as fibronectin or lipocalin, providing versatility for different applications in research and industry.
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