Calcitonin Gene-Related Peptides (CGRP) and Fragments

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CAT# Product Name M.W Molecular Formula Inquiry
C05002 [Tyr0] Calcitonin Gene Related Peptide (28-37), rat 1182.3 C54H79N13O17 Inquiry
C05003 α-CGRP (23-37) (human) 1620.87 C74H117N21O20 Inquiry
C05004 Tyr-α-CGRP (23-37) (canine, mouse, rat) 1785.97 C82H120N20O25 Inquiry
C05005 Calcitonin Gene Related Peptide (20-37), human 1834.1 C83H132N24O23 Inquiry
C05007 Acetyl-α-CGRP (19-37) (human) 1963.22 C88H139N25O26 Inquiry
C05008 Calcitonin Gene Related Peptide (1-19), human 1973.3 C80H137N27O27S2 Inquiry
C05009 α-CGRP (8-37) (human) 3125.63 C139H230N44O38 Inquiry
C05010 α-CGRP (8-37) (canine, mouse, rat) 3127.56 C138H224N42O41 Inquiry
C05011 Calcitonin Gene Related Peptide, CGRP, human 3789.4 Inquiry
C05013 Calcitonin Gene Related Peptide II, rat 3805.4 C163H267N51O50S2 Inquiry
C05015 Calcitonin Gene Related Peptide, CGRP, chicken 3838.4 Inquiry
C05019 [Tyr0] Calcitonin Gene Related Peptide, rat 3970.0 C171H271N51O54S2 Inquiry
C05022 α-CGRP (33-37) (canine, mouse, porcine, rat) 508.54 C22H32N6O8 Inquiry
C05023 α-CGRP (32-37) (canine, mouse, porcine, rat) 607.66 C27H41N7O9 Inquiry
C05024 α-CGRP (31-37) (canine, mouse, rat) 721.77 C31H47N9O11 Inquiry
C05025 α-CGRP (30-37) (canine, mouse, rat) 822.87 C35H54N10O13 Inquiry
C05026 α-CGRP (29-37) (canine, mouse, rat) 919.99 C40H61N11O14 Inquiry
C05027 (Cys(Acm)2·7)-alpha-CGRP (human) 3933.53 Inquiry
C05028 (Cys(Et)2·7)-alpha-CGRP (human) 3847.48 Inquiry
C05029 (Tyr27)-alpha-CGRP (27-37) (canine, mouse, rat) 1182.3 Inquiry

Introduction

Calcitonin gene-related peptide (CGRP) is the first neuropeptide that is genetically recombined and biosynthesized. CGRP is a well-characterized peptide consisting of 37 amino acids. There are two subtypes of α and β, which are encoded by the α-CGRP gene and the β-CGRP gene, respectively. It is distributed in the central and peripheral tissues. α-CGRP is widely expressed in the central and peripheral nervous systems. The expression of β-CGRP is relatively restricted, but it is also present throughout the central nervous system, vasculature, and enteric nerves.

Mechanism of action

CGRP is a major neurotransmitter of capsaicin-sensitive sensory nerves, which is synthesized in neuronal bodies and stored in nerve endings. The synthesis and release of CGRP is regulated by a variety of factors. The transient receptor potential channel vanilloid type 1 (TRPV1) is a key receptor regulating the synthesis and release of CGRP. TRPV1 binding site is located inside the cell membrane. TRPV1's endogenous ligand, anandamide, is transported into the cell by the transporter to function. CGRP interacts with CGRP receptors to exert an effect.

Application of CGRP

CGRP has a wide and complex biological effect. In nerve tissue, CGRP is associated with neuralgia and migraine attacks. In the cardiovascular system, in addition to regulating vascular tone and maintaining circulatory stability, CGRP can also reduce ischemic injury, inhibit myocardial fibroblast proliferation and cardiac remodeling. In the gastrointestinal tract, CGRP has a protective effect on the gastric mucosa. CGRP is involved in the pathophysiological processes of various cardiovascular diseases such as hypertension, myocardial infarction, heart failure and pulmonary hypertension. Exogenous CGRP can be used to treat hypertension, pulmonary hypertension, acute lung injury, brain and heart ischemia-reperfusion injury, and chronic heart failure. Therefore, it is speculated that affecting the synthesis and release of endogenous CGRP may be a new way to find new drugs.

Reference

  1. Chai, W., Mehrotra, S., Jan Danser, A.H., Schoemaker, R.G. (2006) The role of calcitonin gene- related peptide (CGRP) in ischemic preconditioning in isolated rat hearts. Eur J Pharmacol, 531: 246-253.
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