Calcitonins and Calcitonin Precursors Peptides

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CAT# Product Name M.W Molecular Formula Inquiry
C06001 Calcitonin C-terminal Adjacent Peptide, rat 1889 Inquiry
C06003 Calcitonin C-Terminal Flanking Peptide (human) 2436.63 C97H154N34O36S2 Inquiry
C06006 Calcitonin, chicken 3371.9 Inquiry
C06007 Calcitonin, rat 3399.9 Inquiry
C06008 Calcitonin, eel 3414.9 Inquiry
C06009 Calcitonin (human) 3417.90 C151H226N40O45S3 Inquiry
C06010 Calcitonin (salmon I) 3431.90 C145H240N44O48S2 Inquiry
C06011 Glu20-salmon calcitonin 3432.9 C145H239N43O49S2 Inquiry
C06012 Calcitonin, porcine 3604.1 Inquiry
C06020 Calcitonin (1-7), human 694.8 C25H42N8O11S2 Inquiry
C06021 (Des-Cys1,cyclo(Ser2-Asu7))-Calcitonin (eel) 3363.82 Inquiry
C06022 Biotinyl-(Cys1,Lys(biotinyl)18)-Calcitonin (human) 3870.5 Inquiry
C06023 Biotinyl-Calcitonin (salmon I) 3658.2 Inquiry


Calcitonin is a polypeptide hormone consisting of 32 amino acids that inhibits bone resorption by inhibiting the activity of osteoclasts. In humans, the precursor of calcitonin is a glycoprotein. The carboxy terminal is a precursor of glycine by protease cleavage. Further, it is processed into a mature calcitonin having an amide group at the carboxy terminal by the action of peptidylglycine α-amidase. Calcitonin was first discovered by Hirsh and demonstrated its calcium-phosphorus metabolism regulation. It has shown good results in the treatment of osteoporosis, hypercalcemia, hyperparathyroidism, osteoarthritis and bone healing. The clinically used calcitonin is mainly a non-human calcitonin isolated and purified from the squid and porcine thyroid gland.

Mechanism of action

Studies have shown that calcitonin-induced signaling regulates the excitability of primary afferents via the calcitonin receptor, thereby controlling Na+ channel transcription in the dorsal root ganglia. The accumulation and maintenance of calcitonin-induced signals and the further breakdown of the calcitonin receptor-mediated system in peripheral nerve tissue are one of the strategies for relieving neuropathic pain. Ito et al reported that in ovariectomized-induced hyperalgesia rats, treatment with calcitonin at the end of the spinal cord in response to pain increased the level of high-threshold Na+ channel expression. This indicates that the recovery of the descending inhibition system is also conducive to the appearance of the analgesic effect.

Application of Calcitonins and Calcitonin Precursors Peptides

Studies have shown that calcitonin selectively improves the chronic contractile injury of rats to enhance the arterial contractility, thereby exerting its mitigation effect on peripheral circulatory disorders. Calcitonin increases the level of endogenous opioid metabolites and thus acts to relieve pain. Osteoporosis causes vertebral deformation and ultimately leads to small joint damage. Lumbar osteoporosis causes microfracture of the vertebral body, resulting in loss of vertebral height, disorder of intervertebral disc and facet joint, and triggering arthritis. Calcitonin is used to treat osteoporosis by promoting bone mineralization and improving bone structure. Calcitonin and its precursor peptides have a good effect on the symptoms of bone pain caused by many bone metabolic diseases.


  1. Hirsch, P.F., Munson, P.L. (1969) Thyrocalcitonin. Physiol Rev, 49(3): 548-622.
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