Defensins

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CAT# Product Name M.W Molecular Formula Inquiry
D01001 Defensin (human) HNP-2 3371.0 C147H217N43O37S6 Inquiry
D01002 Defensin-1 (human) HNP-1 3442.1 C150H222N44O38S6 Inquiry
D01003 α-Defensin 6 3708.27 C156H228N46O46S7 Inquiry
D01004 Defensin HNP-3 (human) 3486.09 C151H222N44O40S6 Inquiry
D01005 Corticostatin I (rabbit) 3997.64 Inquiry
D01007 rec beta-Defensin 1 (human) Inquiry
D01008 rec beta-Defensin 2 (human) Inquiry
D01009 Retrocyclin-1 1918.42 Inquiry
D06001 Defensin-like peptide 1 Inquiry
D06002 Defensin-like peptide 2/4 Inquiry
D06003 Defensin-like protein 2 Inquiry
D06004 Defensin-like protein 4 Inquiry
D06005 Defensin-like protein 16 Inquiry
D06006 Alpha-defensin-related sequence 10 Inquiry
D06007 Alpha-defensin-related sequence 2 Inquiry
D06008 Defensin-like protein 17 Inquiry
D06009 Defensin-like protein 1 Inquiry
D06010 Defensin-like protein 5 Inquiry
D06011 Defensin-like protein 13 Inquiry
D06012 CHRG01; Human β-Defensin 3 (hBD3) Derivative 1662 Inquiry

Introduction

The defensin was first named by Robert Lehrer of the United States in 1980. It is a small molecule short peptide that can antagonize microorganisms and some malignant cells produced by the organism in the defense against pathogens. Defensins usually consist of 29 to 54 amino acids, including 6 to 8 conserved cysteines, which form an antiparallel β-sheet or alpha-helical structure through a cysteine intramolecular disulfide bond. Defensin is structurally stable and has a very broad spectrum of antibacterial activity. It can be divided into animal defensins, plant defensins and insect defensins depending on the source. Defensin has a stable molecular structure and a broad spectrum of antibacterial activity. According to different molecular structural characteristics, animal defensins can be divided into three types: α-defensin, β-defensin, and θ-defensin.

Mechanism of action

The antibacterial mechanism of defensin has two different mechanisms of antibacterial action, one is the independent membrane mechanism, and the other is the mechanism by which defensin binds to intracellular complexes. The independent membrane mechanism holds that positively charged defensins and negatively charged bacterial cell membranes attract each other and bind to each other, thereby destroying the integrity of the phospholipid bilayer and causing fissures in the target cell membrane.

Application of defensins

Studies have found that defensins in intestinal epithelial cells play a natural barrier to the intestinal mucosa, and the decrease in the expression level of defensins leads to adhesion of mucosal bacteria and invasion of the body to trigger an inflammatory response. Chronic inflammatory diseases of the intestine, Crohn' disease (CD) and ulcerative colitis (UC), are associated with abnormal expression of the ileal Pandemic cell defenses HD-5 and HD-6. Defensins have a relationship with chronic obstructive pulmonary disease. Defensin HBD-2 is closely related to respiratory diseases and plays an important role in lung mucosal defense. PMX-30063 is an antibiotic drug that mimics defensins and has a completely new mechanism of action, and bacteria are less susceptible to resistance. It is active against both Gram-positive and Gram-negative bacteria, it kills cells directly and sterilizes faster than many antibiotics.

References

  1. Kovalzon, V. M. , & Strekalova, T. V. . (2006). Delta sleep-inducing peptide (dsip): a still unresolved riddle . Journal of Neurochemistry, 97(2), 7.
  2. Bobyntsev, I. I. , Kryukov, A. A. , Belykh, A. E. , & Dudka, V. T. . (2016). Effect of delta sleep-inducing peptide on functional state of hepatocytes in rats during restraint stress. Bulletin of Experimental Biology and Medicine, 160(4), 421-424.
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