With rich experience in peptide synthesis, Creative Peptides provides a series of antigen peptide services to generate an appropriate peptide antigen for the antibody generation process, and has developed a professional peptide evaluation tool to assist in the design of new antigen peptides.
Multiple antigen peptides (MAPs) are a kind of radially branched polymeric peptide macromolecules, composed of a branched peptide core and surface-active peptides connected by covalent bonds, which are different from the traditional linear peptide complexes on the tandem amino acid backbone. It has a high enough molar ratio of antigen to core that it can be used as an immunogen without the need to connect to the carrier protein.
In its original design, MAP was a simple dendron radiating directly from the lysine core, but the concept can be naturally extended to more tree-like constructs where a single sequence ('tail', see Reaction Scheme) forks out into 2n branches (n usually ≤3). Like other dendrimers, MAPs can be synthetically approached by divergent or convergent methods. The synthesis of MAP can be problematic, as the strict spacing between each of the eight branches might lead to aggregation of the peptides on the resin. This could result in low coupling yields and peptide deletions. Creative Peptides has developed a synthesis strategy for MAPs to overcome these issues, which allows the production of the desired peptide dendrimer at an increased yield.
MAPs are polymeric peptides with a branched structure, consisting of a central peptide core and surface-active peptides. Unlike traditional linear peptides, MAPs can function as immunogens without needing a carrier protein.
MAP synthesis involves creating a dendritic structure with peptide sequences branching out from a central core, which is typically achieved using divergent or convergent methods. Creative Peptides has optimized this process to ensure higher yields and better peptide quality.
MAPs provide a high molar ratio of antigen to core, which allows them to be highly effective in generating immune responses. They are also more stable and versatile compared to traditional peptide formulations.
Yes, Creative Peptides can synthesize MAPs with peptide chains up to 70 amino acids, ensuring that long peptide sequences can be incorporated while maintaining quality and function.
Our optimized synthesis strategy ensures that MAPs are produced with high yield and minimal aggregation, which often complicates the synthesis process in traditional methods. We also offer a peptide assessment tool to help design more effective antigenic peptides.
MAPs typically consist of surface-active peptides that are branched from a central lysine core. These peptides can be tailored based on the target antigen's characteristics, providing flexible options for custom antigen design.
The purity of our MAP peptides can reach over 98% through rigorous HPLC purification and mass spectrometry analysis, ensuring high-quality products for research purposes.
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