Angiotensin and Related Peptides

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CAT# Product Name M.W Molecular Formula Inquiry
A15002 Angiotensin A 1002.18 C49H71N13O10 Inquiry
A15003 [Sar1] Angiotensin II 1002.2 C49H71N13O10 Inquiry
A15005 Angiotensin (1-5), FAM--labeled 1023.1 Inquiry
A15006 [Asn1,Val5] Angiotensin II 1031.2 C49H70N14O11 Inquiry
A15007 [Val5] Angiotensin II, human 1032.2 C46H69N13O12 Inquiry
A15008 Angiotensin II, flounder 1045.22 C50H72N14O11 Inquiry
A15009 Angiotensin II, human 1046.2 Inquiry
A15012 Angiotensin II, human, acetylated 1088.2 Inquiry
A15013 Angiotensin Converting Enzyme Inhibitor, BPP 9a 1101.3 Inquiry
A15017 [Des-Asp1]-Angiotensin I, human 1181.4 Inquiry
A15018 Angiotensin (1-9) 1183.3 Inquiry
A15019 HRP Prorenin, Decoy Handle Region (31-40), rat 1184.6 Inquiry
A15021 [Asn1, Val5, Asn9] Angiotensin I, salmon 1258.5 C59H87N17O14 Inquiry
A15022 (Val5,Asn9)-Angiotensin I 1259.43 C59H86N16O15 Inquiry
A15023 Prorenin Peptide (33-42) 1260.6 Inquiry
A15024 [Ala-Pro-Gly-(Ile3,Val5)] Angiotensin II 1271.5 C60H86N16O15 Inquiry
A15025 [Val5] Angiotensin I, bovine 1282.5 C61H87N17O14 Inquiry
A15028 Acetyl-Angiotensin I 1338.53 C64H91N17O15 Inquiry
A15033 Angiotensin (1-12) (human) 1508.79 C73H109N19O16 Inquiry
A15036 Angiotensin (1-12) (mouse, rat) 1572.83 C77H109N19O17 Inquiry

Introduction

The renin angiotensin system (RAS) is an important regulatory system for maintaining blood pressure, water and electrolyte balance, and cardiovascular homeostasis. Angiotensinogen is metabolized by renin to produce angiotensin I (AngI). Then AngI can be converted to angiotensin II (AngII) under the action of angiotensin-converting enzyme (ACE). It has been found that AngII is not the only biologically active molecule in angiotensin metabolites. Except for the well-known AngI (Ang1-10), AngII (Ang1-8), AngIII (Ang2-8) and AngIV (Ang3-8), there are many degradation products of angiotensin in the body, such as Ang1-9, Ang1-7, Ang1-5, etc.

Mechanism of action

Among the members of angiotensin metabolism, AngI has only weak biological effect and is a substrate for a series of angiotensin hydrolysates. AngII exerts a variety of biological effects by binding to its specific AT1 and AT2 receptors, including strong vasoconstriction, elevation of hypertension, and promotion of vascular smooth muscle cell proliferation. In addition, AngII is responsible for the regulation vascular tone, the release of pro-inflammatory cytokines and the activation of the transcription factor NFκB. It inhibits the synthesis of nitric oxide (NO), and is widely involved in the pathogenesis of atherosclerosis, hypertension, congestive heart failure, and stroke.

Application of Angiotensins and Related Peptides

At present, the drugs targeting angiotensins and related peptides have been developed. For example, ACEI, the inhibitor of ACE and ARBs, is angiotensinII receptor blocker. Except for ACEI and ARBs, drugs for the downstream molecules of the RAS have made great contributions to the treatment of a variety of cardiovascular diseases, including essential hypertension, heart failure, etc. Recent studies have found that various metabolic peptides derived from angiotensinogen not only have relatively independent biological effects, but also that these different active fragments interact with each other in metabolic and biological effects. Understanding the relationship of the network regulation between angiotensin metabolism fragments helps to elucidate the mechanisms of cardiovascular disease and explore new targets for its prevention and treatment.

References

  1. Ruiz-Ortega M, Lorenzo O, Suzuki Y, et al. Proinflammatory actions of angiotensins.[J]. Curr Opin Nephrol Hypertens, 2001, 10(3):321-329.
  2. Kehoe P G. Angiotensins and Alzheimer's disease: a bench to bedside overview[J]. Alzheimers Research & Therapy, 2009, 1(1):3.
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