Beta-Secretase Inhibitor 1

Name: Beta-Secretase Inhibitor 1
Brand: Creative Peptides
SKU: A13083
Availability: MadeToOrder

This statine-based substrate analog, ?-secretase inhibitor P10–P4’ statV, is used in the inhibition of ?-secretase activity from homogenized wild-type mouse cortices and from BACE-purified from human brain.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: A13083

Custom Peptide Synthesis

cGMP Peptide

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.F/Formula

1651.9

Sequence

One Letter Code: KTEEISEVN-Sta-VAEF (Sta = statine)
Three Letter Code: H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-OH

Length

References

Sinha, S. et al. Nature 402, 537 (1999).

1. High fat diet and GLP-1 drugs induce pancreatic injury in mice

2. Implications of ligand-receptor binding kinetics on GLP-1R signalling

3. Myotropic activity of allatostatins in tenebrionid beetles

4. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

5. TMEM16F and dynamins control expansive plasma membrane reservoirs

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