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CAT# | Product Name | M.W | Molecular Formula | Inquiry |
---|---|---|---|---|
H09874 | C34 gp41 HIV Fragment | 4248.6 | Inquiry | |
HB00158 | HIV (gp120) Fragment (254-274) | 2208.57 | C95H162N28O30S | Inquiry |
HB00159 | HIV-1 env Protein gp120 (278-292) (strains BH10, BH8, HXB2, HXB3, PV22) | 1655.97 | C73H126N26O18 | Inquiry |
HB00160 | HIV (gp120) Fragment (308-331) | 2640.09 | C114H199N41O31 | Inquiry |
HB00161 | HIV (gp120) Fragment (421-438) trifluoroacetate salt | 2138.54 | C99H148N24O25S2 | Inquiry |
HB00163 | HIV (gp120) Fragment (318-327) | 1073.26 | C48H80N16O12 | Inquiry |
HB00164 | HIV-1 gag Polyprotein (121-140) | 2080.2 | C86H138N26O34 | Inquiry |
HB00165 | HIV (gp120) Antigenic Peptide trifluoroacetate salt | 2720.29 | C117H211N41O31S | Inquiry |
HB00166 | HIV-1 gag Protein p24 (194-210) | 2076.49 | C92H158N26O26S | Inquiry |
HB00167 | HIV-1 gag Protein p24 (65-73) (isolates MAL/U455) trifluoroacetate salt | 1050.31 | C44H79N11O14S2 | Inquiry |
HB00168 | C34 - LC - Biotin, gp41 HIV fragment | 4715.3 | Inquiry |
The gag gene encodes the Gag precursor protein of 55kD, also known as P55 protein. When Gag is translated and expressed, the N-terminal is modified by cardamom acylation, which promotes its binding to the cytoplasmic side of the cell membrane. The Gag polyprotein bound to the membrane recruits two copies of the viral genomic RNA, together with other viruses and cell proteins, to trigger viral particles to sprout and secrete from the infected cell surface. After budding, Gag is cut by virus-encoded proteases into four smaller proteins: MA (matrix proteins, also known as p17), CA (capsid protein, also known as p24), NC (nucleocapsid protein, also known as p9) and p6.
Human immunodeficiency virus (HIV-1) is a retrovirus that can cause acquired immunodeficiency syndrome (AIDS), which is a highly fatal infectious disease. Gag protein is not only the main structural protein of HIV-1, but also the necessary structural protein for HIV-1 spherical capsid assembly. The in-depth study of the transport, polymerization and assembly of Gag protein is helpful to further understand the replication mechanism of HIV-1, and accelerate the development of new and efficient antiviral drugs.
References
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