α-conotoxin GI, a conopeptide isolated from the venom of the cone snail Conus geographus, is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors (nAChR) such as α-conotoxin MI or d-Turbocurarine.
CAT# | C27003 |
CAS | 76862-65-2 |
Synonyms/Alias | alpha-conotoxin GI |
Chemical Name | (4S)-4-amino-5-[[(1R,7S,10S,13S,16S,19R,24R,27S,33S,36S,43R)-27-(2-amino-2-oxoethyl)-19-carbamoyl-7-[3-(diaminomethylideneamino)propyl]-16-(hydroxymethyl)-13-[(4-hydroxyphenyl)methyl]-10-(1H-imidazol-5-ylmethyl)-36-methyl-2,5,8,11,14,17,25,28,34,37,44-undecaoxo-21,22,40,41-tetrathia-3,6,9,12,15,18,26,29,35,38,45-undecazatricyclo[22.14.7.029,33]pentatetracontan-43-yl]amino]-5-oxopentanoic acid |
M.F/Formula | C55H80N20O18S4 |
M.W/Mr. | 1437.6 |
Sequence | One Letter Code: ECCNPACGRHYSC Three Letter Code: H-Glu-Cys(1)-Cys(2)-Asn-Pro-Ala-Cys(1)-Gly-Arg-His-Tyr-Ser-Cys(2)-NH2 |
Application | ADCs Cytotoxin |
Appearance | White lyophilized solid |
Activity | Antagonist |
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