Alpha-conotoxin GI

α-conotoxin GI, a conopeptide isolated from the venom of the cone snail Conus geographus, is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors (nAChR) such as α-conotoxin MI or d-Turbocurarine.

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Synonyms/Aliasalpha-conotoxin GI
Chemical Name(4S)-4-amino-5-[[(1R,7S,10S,13S,16S,19R,24R,27S,33S,36S,43R)-27-(2-amino-2-oxoethyl)-19-carbamoyl-7-[3-(diaminomethylideneamino)propyl]-16-(hydroxymethyl)-13-[(4-hydroxyphenyl)methyl]-10-(1H-imidazol-5-ylmethyl)-36-methyl-2,5,8,11,14,17,25,28,34,37,44-undecaoxo-21,22,40,41-tetrathia-3,6,9,12,15,18,26,29,35,38,45-undecazatricyclo[,33]pentatetracontan-43-yl]amino]-5-oxopentanoic acid
SequenceOne Letter Code: ECCNPACGRHYSC
Three Letter Code: H-Glu-Cys(1)-Cys(2)-Asn-Pro-Ala-Cys(1)-Gly-Arg-His-Tyr-Ser-Cys(2)-NH2
ApplicationADCs Cytotoxin
AppearanceWhite lyophilized solid
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